Chronic glomerular nephritis in a man with an IgM cold autoantibody of anti-I specificity and a cold lymphocytotoxic antibody
Chronic glomerular nephritis in a man with an IgM cold autoantibody of anti-I specificity and a cold lymphocytotoxic antibody
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一名男性患有慢性肾小球肾炎，具有抗 I 特异性 IgM 冷自身抗体和冷淋巴细胞毒性抗体
DOI：
10.1136/jcp.25.3.247
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发表时间：
1972
影响因子：
3.4
通讯作者：
T. Mitchell
中科院分区：
文献类型：
--
作者：
R. Bailey;M. el;I. Balfour;T. Mitchell
这篇文章描述了一个患有慢性肾小球肾炎的年轻人，他的血清中含有针对红细胞和淋巴细胞的冷抗体。肾活检显示异常的组织学特征，包括IgM和补体的广泛沉积。虽然异常的免疫反应在慢性肾功能衰竭中并不少见，但这表明潜在的肾脏病变和异常抗体之间可能存在因果关系。
This communication describes a young man with chronic glomerular nephritis whose serum contained cold antibodies directed against both red cells and lymphocytes. A renal biopsy revealed unusual histological features including extensive deposits of IgM and complement. Although abnormal immune responses are not uncommon in chronic renal failure, it is suggested that there may be a causal relationship between the underlying renal lesion and the abnormal antibodies.