Platelet serotonin levels in schizophrenia: relationship to race and psychopathology.
Platelet serotonin levels in schizophrenia: relationship to race and psychopathology.
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DOI：
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发表时间：
1983
影响因子：
10.6
通讯作者：
H. Jackman;D. Luchins;H. Meltzer
中科院分区：
文献类型：
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作者：
H. Jackman;D. Luchins;H. Meltzer
为探讨5-羟色胺（5-HT）在精神分裂症发病中的作用，测定了41例经RDC诊断的精神分裂症（及情感性，主要为精神分裂症）患者和34例正常人血小板5-HT含量。有一个显着的患者和对照组之间的差异与16偏执，11未分化，和8情感性抑郁症患者有显着较高的平均血小板5-HT浓度比对照组。考虑种族、性别和诊断影响的方差分析显示，黑人患者和黑人对照组之间存在显著差异，但白色患者和白色对照组之间无显著差异。在患者样本中，血小板5-HT浓度与幻听（PSE）的严重程度呈正相关，与缺乏洞察力（PSE）和概念混乱（BPRS）呈负相关。在21例患者的子样本中，血小板5-HT与脑室扩大或皮质萎缩的CT结果之间没有关系。
To explore the possible role of serotonin (5-HT) in the etiology of schizophrenia, platelet 5-HT concentrations were determined in 41 schizophrenic (and schizoaffective, mainly schizophrenic) patients diagnosed by the RDC and 34 normal controls. There was a significant difference between the patient and control groups with the 16 paranoid, 11 undifferentiated, and 8 schizo-affective depressed patients having significantly higher mean platelet 5-HT concentrations than the controls. An analysis of variance considering the effect of race, sex, and diagnosis demonstrated a significant difference between black patients and black controls but no significant difference between white patients and white controls. Within the patient sample, platelet 5-HT concentrations were positively correlated with severity of auditory hallucinations (on the PSE) and negatively correlated with lack of insight (on the PSE) and conceptual disorganization (on the BPRS). In a subsample of 21 patients, there was no relationship between platelet 5-HT and CT findings of either enlarged ventricles or cortical atrophy.