ANTIGENIC RELATIONSHIPS AMONG PROTEINS OF BOVINE CORONAVIRUS, HUMAN RESPIRATORY CORONAVIRUS-OC43, AND MOUSE HEPATITIS CORONAVIRUS-A59
ANTIGENIC RELATIONSHIPS AMONG PROTEINS OF BOVINE CORONAVIRUS, HUMAN RESPIRATORY CORONAVIRUS-OC43, AND MOUSE HEPATITIS CORONAVIRUS-A59
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DOI：
10.1128/jvi.51.2.384-388.1984
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发表时间：
1984-01-01
影响因子：
5.4
通讯作者：
BRAIN, DA
中科院分区：
文献类型：
--
作者：
HOGUE, BG;KING, B;BRAIN, DA
针对牛冠状病毒（Mebus株）的3种单一和1对主要结构蛋白制备的抗血清用于免疫印迹研究，以测量与人冠状病毒OC 43和小鼠肝炎冠状病毒A59的结构蛋白的交叉反应性。牛冠状病毒由4种主要结构蛋白组成，gp190（通常以120和100千道尔顿亚基存在），gp140，pp52和gp26。人类冠状病毒OC 43与这些蛋白质中的每一种具有相似分子量的抗原同源对应物。小鼠肝炎冠状病毒A59仅与其中3种蛋白质具有抗原同源性对应物：gp190、pp52和gp26。在小鼠病毒中没有与gp140（牛冠状病毒的明显血凝素）对应的病毒。
Antisera prepared against each of 3 single and 1 pair of major structural proteins of the bovine coronavirus (Mebus strain) were used in immunoblotting studies to measure cross-reactivity with the structural proteins of the human coronavirus OC43 and the mouse hepatitis coronavirus A59. The bovine coronavirus is comprised of 4 major structural proteins, gp190 (normally present as 120- and 100-kilodalton subunits), gp140, pp52 and gp26. The human coronavirus OC43 has an antigenically homologous counterpart of similar molecular mass to each of these proteins. The mouse hepatitis coronavirus A59 has an antigenically homologous counterpart to only 3 of these proteins: gp190, pp52 and gp26. There is no counterpart in the mouse virus to gp140, the apparent hemagglutinin of the bovine coronavirus.