Sono-photoacoustic imaging of gold nanoemulsions: Part I. Exposure thresholds.
Sono-photoacoustic imaging of gold nanoemulsions: Part I. Exposure thresholds.
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DOI：
10.1016/j.pacs.2014.12.001
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发表时间：
2015-03
期刊：
影响因子：
7.9
通讯作者：
O'Donnell M
中科院分区：
文献类型：
--
作者：
Arnal B;Perez C;Wei CW;Xia J;Lombardo M;Pelivanov I;Matula TJ;Pozzo LD;O'Donnell M
研究了将来自超声成像的高对比度气泡与来自光声成像的等离子体吸收体集成。用同时的光（GNS处的瞬时热）和超声（稀疏压力）激发涂覆有金纳米球（NEB-GNS）的纳米乳液珠，从而导致在不同情况下可实现的相变，增强激光诱导的声学信号并使得能够在较低浓度下特异性检测纳米探针。一个自动化的平台允许双参数扫描的压力和激光通量，同时记录宽带声信号。两种类型的NEB-GNS和个人GNS进行了研究，并显示了这种技术的巨大潜力，以增强光声/声信号。NEB-GNS尺寸分布影响汽化阈值，其可以在允许的超声和光暴露下在深穿透和低浓度目标下达到。这种技术被称为声光声学，具有很大的潜力，有针对性的分子成像和治疗使用紧凑的纳米探针具有潜在的高穿透性到组织。
Integrating high contrast bubbles from ultrasound imaging with plasmonic absorbers from photoacoustic imaging is investigated. Nanoemulsion beads coated with gold nanopsheres (NEB-GNS) are excited with simultaneous light (transient heat at the GNS's) and ultrasound (rarefactional pressure) resulting in a phase transition achievable under different scenarios, enhancing laser-induced acoustic signals and enabling specific detection of nanoprobes at lower concentration. An automated platform allowed dual parameter scans of both pressure and laser fluence while recording broadband acoustic signals. Two types of NEB-GNS and individual GNS were investigated and showed the great potential of this technique to enhance photoacoustic/acoustic signals. The NEB-GNS size distribution influences vaporization thresholds which can be reached at both permissible ultrasound and light exposures at deep penetration and at low concentrations of targets. This technique, called sono-photoacoustics, has great potential for targeted molecular imaging and therapy using compact nanoprobes with potentially high-penetrability into tissue.