Patterned enteroscopy balloon design factors influence tissue anchoring
Patterned enteroscopy balloon design factors influence tissue anchoring
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DOI：
10.1016/j.jmbbm.2020.103966
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发表时间：
2020-11-01
影响因子：
3.9
通讯作者：
Rentschler, Mark E.
中科院分区：
文献类型：
--
作者：
Bowen, Leah K.;Johannes, Karl;Rentschler, Mark E.
球囊辅助肠镜检查程序可以对小肠进行可视化和干预。这些气球将内窥镜和/或外套管固定在小肠上，允许内窥镜医生将小肠折叠在外套管上。该手术可以将检查范围延伸到小肠深处，超出内窥镜直接检查所允许的长度。然而，由于球囊滑动，手术常常会延长或不完整。为了确保患者安全，肠镜球囊受到压力限制，因此在不增加压力的情况下改善锚定至关重要。具有离散特征的球囊外部图案可以增强组织-球囊界面处的锚定。在这里，探索图案设计空间以确定影响组织锚定的因素。通过实验测量诱导离体猪小肠内充气气球滑动所需的峰值力，研究了光滑气球与具有图案特征的气球的锚定能力。与光滑的硅胶球囊相比，更硬的材料、低纵横比特征以及球囊上的图案区域/位置显着增加了峰值力。用于标准肠镜检查的光滑乳胶球囊具有最低的峰值力。这项工作展示了一种对曲面进行图案化的方法，以及具有图案化特征的球囊改善了对可变形、润滑的组织界面的锚定。
Balloon-assisted enteroscopy procedures allow visualization and intervention in the small intestine. These balloons anchor an endoscope and/or overtube to the small intestine, allowing endoscopists to plicate the small intestine over the overtube. This procedure can extend examination deeper into the small intestine than the length of the endoscope would allow with direct examination. However, procedures are often prolonged or incomplete due to balloon slippage. Enteroscopy balloons are pressure-limited to ensure patient safety and thus, improving anchoring without increasing pressure is essential. Patterning balloon exteriors with discrete features may enhance anchoring at the tissue-balloon interface. Here, the pattern design space is explored to determine factors that influence tissue anchoring. The anchoring ability of smooth versus balloons with patterned features is investigated by experimentally measuring a peak force required to induce slippage of an inflated balloon inside ex-vivo porcine small intestine. Stiffer materials, low aspect-ratio features, and pattern area/location on the balloons significantly increase peak force compared to smooth silicone balloons. Smooth latex balloons, used for standard enteroscopy, have the lowest peak force. This work demonstrates both a method to pattern curved surfaces and that a balloon with patterned features improves anchoring against a deformable, lubricated tissue interface.