Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury

Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury
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肝损伤期间一氧化氮水平升高与肝细胞凋亡相关

DOI:
10.1111/hepr.12783
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发表时间:
2017-02
影响因子:
4.2
通讯作者:
Yang Shulong
Yang Shulong
中科院分区:
医学2区
文献类型:
--
作者:
Liu Hui;Li Qian;Wang Ying;Hong Huimin;Chen Mengting;Wang Yingyi;Hong Fenfang;Yang Shulong

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肝损伤是肝移植等肝脏手术中的重大事件,它往往会导致肝细胞凋亡。一氧化氮(NO)是一种关键的信号调节分子。许多研究人员已表明,一氧化氮水平升高会对肝脏产生影响。
Hepatic injury is a major event in liver surgery such as liver transplantation and it always leads to hepatic cell apoptosis. Nitric oxide (NO) is a key signaling regulation molecule. Many researchers have shown that increased NO level can influence liver cell apoptosis by promoting or inhibiting the relative signaling pathways that are involved in the caspase family, Bax/Bcl‐2, mitochondria, oxidative stress, death receptors, and mitogen‐activated protein kinases. Elucidating the relationships between NO and hepatic cell apoptosis is necessary for ameliorating prognosis of liver surgery. This article reviews the newest research progress in the relationships between higher NO levels and hepatic cell apoptosis in liver injury.
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