Restraining and unleashing chromatin remodelers - structural information guides chromatin plasticity
Restraining and unleashing chromatin remodelers - structural information guides chromatin plasticity
复制标题
DOI：
10.1016/j.sbi.2020.06.008
复制
发表时间：
2020-12-01
影响因子：
6.8
通讯作者：
Ladurner, Andreas G.
中科院分区：
文献类型：
--
作者：
Blessing, Charlotte;Knobloch, Gunnar;Ladurner, Andreas G.
染色质重塑酶是通过重组染色质结构来保护基因组的大分子机器。它们可以重新定位、分隔和排出核小体，从而控制基因表达、DNA复制和修复。最近的低温电子显微镜（cryo-EM）分析已经捕获了各种染色质重塑物与核小体相互作用的快照。本文就染色质重塑子调控、DNA易位模式、相关蛋白结构域和重塑子亚基对染色质重塑复合物特定功能的影响等方面的研究进展进行综述和讨论。新出现的结构信息将有助于我们对疾病机制的理解，并指导我们对创新治疗干预的认识。
Chromatin remodeling enzymes are large molecular machines that guard the genome by reorganizing chromatin structure. They can reposition, space and evict nucleosomes and thus control gene expression, DNA replication and repair. Recent cryo-electron microscopy (cryo-EM) analyses have captured snapshots of various chromatin remodelers as they interact with nucleosomes. In this review, we summarize and discuss the advances made in our understanding of the regulation of chromatin remodelers, the mode of DNA translocation, as well as the influence of associated protein domains and remodeler subunits on the specific functions of chromatin remodeling complexes. The emerging structural information will help our understanding of disease mechanisms and guide our knowledge toward innovative therapeutic interventions.