Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality.
Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality.
复制标题
胞质 TGM2 通过抑制 TRIM21 介导的 GTP 结合依赖方式的 STAT1 泛素化/降解来促进胃癌恶性进展
DOI：
10.1002/cac2.12386
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发表时间：
2023-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
Previous studies have revealed the critical role of transglutaminase 2 (TGM2) as a potential therapeutic target in cancers, but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer (GC) are not fully understood. In this study, we examined the role and potential mechanism of TGM2 in GC.
影响因子：
3.9
作者：
Dyer, Lisa M.;Schooler, Kevin P.;Ai, Lingbao;Klop, Corinne;Qiu, Jingxin;Robertson, Keith D.;Brown, Kevin D.
通讯作者：
Brown, Kevin D.