Traditional and novel cardiovascular risk factors for retinal vein occlusion: The multiethnic study of atherosclerosis
Traditional and novel cardiovascular risk factors for retinal vein occlusion: The multiethnic study of atherosclerosis
复制标题
DOI：
10.1167/iovs.08-1826
复制
发表时间：
2008-10-01
影响因子：
4.4
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
--
作者：
Cheung, Ning;Klein, Ronald;Wong, Tien Yin
目的。描述视网膜静脉阻塞(RVO)的患病率及其与心血管、炎症和血液学危险因素的关系。方法：这是一项基于人群的横断面研究，研究对象为来自美国6个社区的6147名参与者(白人、黑人、西班牙裔、中国人)。RVO是根据标准化方案从双眼获取的视网膜照片来定义的。结果：RVO的患病率为1.1%(分支RVO为0.9%，中心RVO为0.2%)，不同种族的RVO患病率相似：白人0.9%，黑人1.2%，西班牙裔1.2%，华人1.1%(P=0.76)。与RVO相关的独立危险因素有高血压(优势比[OR]，2.06；95%可信区间[CI]，1.18-3.59)、高龄(OR，1.34；95%CI，1.00-1.81，每十年增加一次)、教育程度低(OR，4.08；95%CI，2.20-7.54)、高甘油三酯血症(OR，1.98；95%CI，1.10-3.56)、肾功能不全(OR，1.85；视网膜动静脉划痕(OR，4.01；95%CI，2.06~7.81)和局灶性小动脉狭窄(OR，4.38；95%CI，1.44~13.34)。RVO与亚临床动脉粥样硬化的直接指标(如颈动脉内膜中层厚度和冠状动脉钙化积分)、炎症标志物(如C反应蛋白、白介素6)和内皮功能障碍(如可溶性细胞间黏附分子-1)或凝血功能(如D-二聚体)无显著相关性。在普通人群中，RVO与高血压、血脂异常和肾功能障碍有关，但与动脉粥样硬化性疾病、全身炎症和血液学异常无关。
PURPOSE. To describe the prevalence of retinal vein occlusion (RVO) and its association with cardiovascular, inflammatory, and hematologic risk factors in a multiethnic cohort.METHODS. This was a population-based, cross-sectional study of 6147 participants (whites, blacks, Hispanics, Chinese) from six U. S. communities. RVO was defined from retinal photographs taken from both eyes according to a standardized protocol. Risk factors were assessed from interviews, examinations, and laboratory and radiologic investigations.RESULTS. The prevalence of RVO was 1.1% (0.9% for branch RVO and 0.2% for central RVO) and was similar across different ethnic groups: 0.9% in whites, 1.2% in blacks, 1.2% in Hispanics, and 1.1% in Chinese (P = 0.76). Independent risk factors associated with RVO were hypertension (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.18-3.59), older age (OR, 1.34; 95% CI, 1.00-1.81, per decade increase), less education (OR, 4.08; 95% CI, 2.20-7.54), hypertriglyceridemia (OR, 1.98; 95% CI, 1.10-3.56), renal dysfunction (OR, 1.85; 95% CI, 1.01-3.39), and the presence of retinal arteriovenous nicking (OR, 4.01; 95% CI, 2.06-7.81) and focal arteriolar narrowing (OR, 4.38; 95% CI, 1.44-13.34). RVO was not significantly associated with direct measures of subclinical atherosclerosis (e. g., carotid intima media thickness and coronary artery calcium scores) or markers of inflammation (e. g., C reactive protein, interleukin-6) and endothelial dysfunction (e. g., soluble intercellular adhesion molecule-1) or coagulation (e. g., D-dimer).CONCLUSIONS. The prevalence of RVO is similar across different racial/ethnic groups. In the general population, RVO is associated with hypertension, dyslipidemia, and renal dysfunction, but not with atherosclerotic disease, systemic inflammation, and hematologic abnormalities.