Early Changes in Circulating Blood Volume and Volume Regulating Humoral Factors After Implantation of an Electrohydraulic Total Artificial Heart
Early Changes in Circulating Blood Volume and Volume Regulating Humoral Factors After Implantation of an Electrohydraulic Total Artificial Heart
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电液全人工心脏植入后早期循环血容量及容量调节体液因子的变化
DOI：
10.1097/00002480-199709000-00067
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发表时间：
1997
期刊：
影响因子：
4.2
通讯作者：
H. Takano
中科院分区：
文献类型：
--
作者：
E. Tatsumi;T. Masuzawa;Y. Sohn;S. Endo;T. Ohno;K. Takiura;T. Nishimura;Y. Takewa;Y. Wakisaka;H. Takano
研究了小牛植入电液全人工心脏（EH-TAH）后循环血量（CBV）和容量调节体液因子的早期变化，并与假手术对照小牛的结果进行了比较。 CBV通过使用吲哚菁绿的染料稀释法测定。定期研究 CBV 和体液因素。在 EH-TAH 植入的小牛中，心输出量估计为 6-7 L/min (94-109 ml/kg/min)，主动脉压和有氧代谢条件良好。尽管如此，术后第 4 天和第 8 天，CBV 分别增加至术前值的 132% 和 168%（对照小腿的范围为 83-103%）。第2、5和7天的心钠素水平分别为23、170和240（对照小牛为19-61）pg/ml，抗利尿激素水平分别为7.3、2.0和1.3（0.5-1.3）pg/ml。血浆肾素活性分别为 3.2、3.7 和 3.1 (0.5–0.3) ng/ml/hr。植入 EH-TAH 的小牛中血管紧张素 I 和血管紧张素 II 水平也有所增加。结论是，即使在 EH-TAH 植入后早期有足够的心输出量，也会发生显着的水潴留。体液因素的变化被认为继发于 CBV 增加或其他未知因素。
The early changes in circulating blood volume (CBV) and volume regulating humoral factors after implantation of an electrohydraulic total artificial heart (EH-TAH) were investigated in a calf and compared with results in a sham operated control calf. CBV was measured by the dye dilution method using indocyanine green. CBV and humoral factors were periodically investigated. In the EH-TAH implanted calf, the cardiac output was estimated at 6–7 L/min (94–109 ml/kg/min), and the aortic pressure and aerobic metabolic condition were favorable. Nevertheless, the CBV was increased to 132 and 168% of the pre-operative value (range in the control calf, 83–103%) on post operative days 4 and 8, respectively. The atrial natriuretic peptide level on days 2, 5, and 7 was 23, 170, and 240 (in the control calf, 19–61) pg/ml, respectively, and the anti-diuretic hormone level was 7.3, 2.0, and 1.3 (0.5–1.3) pg/ml, respectively. The plasma renin activity was 3.2, 3.7, and 3.1 (0.5–0.3) ng/ml/hr, respectively. The angiotensin-I and angiotensin-II levels were also increased in the EH-TAH implanted calf. It is concluded that significant water retention occurs even at sufficient cardiac output early after EH-TAH implantation. The changes in humoral factors are suggested to arise secondary to the increased CBV or other unknown factors.