Intrinsic signal optical imaging of visual brain activity: Tracking of fast cortical dynamics.
Intrinsic signal optical imaging of visual brain activity: Tracking of fast cortical dynamics.
复制标题
视觉大脑活动的内在信号光学成像：跟踪快速皮层动力学
DOI：
10.1016/j.neuroimage.2017.01.006
复制
发表时间：
2017-03-01
期刊：
影响因子：
5.7
通讯作者：
Roe AW
中科院分区：
文献类型：
--
作者：
Lu HD;Chen G;Cai J;Roe AW
基于血液动力学的脑成像技术通常不能以高空间分辨率和高时间分辨率监测脑活动。在这项研究中，我们使用了内在信号光学成像（ISOI），一个相对较高的空间分辨率的成像技术，检查血流动力学信号的时间分辨率。我们成像了麻醉猴对移动光点的V1反应。皮层反应的影像清楚地显示了血流动力学反应的焦点穿过皮层表面。重要的是，在不同的位置沿着皮层轨迹，响应时程保持了类似的三相形状，并转移顺序跨皮层具有可预测的延迟。我们计算了可区分的时间过程之间的时间，发现可以可靠地区分两个事件的信号的时间分辨率约为80毫秒。这些结果表明，基于血流动力学的成像是适合于检测正在进行的皮质事件在高空间分辨率和时间分辨率相关的行为研究。
Hemodynamic-based brain imaging techniques are typically incapable of monitoring brain activity with both high spatial and high temporal resolutions. In this study, we have used intrinsic signal optical imaging (ISOI), a relatively high spatial resolution imaging technique, to examine the temporal resolution of the hemodynamic signal. We imaged V1 responses in anesthetized monkey to a moving light spot. Movies of cortical responses clearly revealed a focus of hemodynamic response traveling across the cortical surface. Importantly, at different locations along the cortical trajectory, response timecourses maintained a similar tri-phasic shape and shifted sequentially across cortex with a predictable delay. We calculated the time between distinguishable timecourses and found that the temporal resolution of the signal at which two events can be reliably distinguished is about 80 milliseconds. These results suggest that hemodynamic-based imaging is suitable for detecting ongoing cortical events at high spatial resolution and with temporal resolution relevant for behavioral studies.