STEROID-PROTEIN INTERACTIONS .14. INTERACTION BETWEEN HUMAN ALPHA1-ACID GLYCOPROTEIN AND PROGESTERONE
STEROID-PROTEIN INTERACTIONS .14. INTERACTION BETWEEN HUMAN ALPHA1-ACID GLYCOPROTEIN AND PROGESTERONE
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DOI：
10.1021/bi00861a022
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发表时间：
1967-01-01
期刊：
影响因子：
2.9
通讯作者：
WESTPHAL, U
中科院分区：
文献类型：
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作者：
GANGULY, M;CARNIGHA.RH;WESTPHAL, U
马尼克. Ganguly、Robert H. Carnighan、f 和 Ulrich Westphal 摘要：人血清中的 cti 酸性糖蛋白（AAG，orosomu-coid）与黄体酮形成相对较强的关联复合物。亲和常数随着温度的升高而降低。相互作用的强度取决于 pH 值；它在pH 8时具有最大值。AAG与各种A4-3-酮类固醇激素之间的结合亲和力遵循“极性规则”。酒精-丙酮沉淀 AAG 会产生“脱脂”制剂，无法与未沉淀的原料区分开来。
Manik. Ganguly, Robert H. Carnighan, f and Ulrich Westphal abstract: The cti-acid glycoprotein (AAG, orosomu-coid) of human blood serum forms a relatively strong association complex with progesterone. The affinity constant decreases with increasing temperature. The strength of interaction is pH dependent; it has a maximal valueat pH 8. The binding affinity between AAG and various A4-3-keto steroid hormones follows the “polarity rule.” Precipitation of AAG by alcohol-acetone results in a “delipidated” preparation which cannot be distinguished from the nonprecipitated ma-