Extragastrointestinal stromal tumor in a kidney transplant recipient
Extragastrointestinal stromal tumor in a kidney transplant recipient
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肾移植受者的胃肠外间质瘤
DOI：
10.1007/s10157-011-0550-x
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发表时间：
2012
影响因子：
2.3
通讯作者：
Jianghua Chen
中科院分区：
文献类型：
--
作者：
H. Tu;Qi Li;Jie;Zhimin Chen;Hao Yang;Hong Jiang;Y. Mao;Z. Shou;Jianghua Chen
在接受免疫抑制治疗的移植后受者中已显示出新发恶性肿瘤的发生。我们介绍一例罕见的胃肠外间质瘤（EGIST），位于肾移植患者的盆腔内。一名57岁女性患者因肾移植后6个月出现非特异性下腹疼痛入院。腹部计算机断层扫描显示盆腔肿瘤肿块直径为 4.5 厘米。肿瘤被整块切除并确认与胃肠壁不相连。显微镜下，肿瘤由典型的梭形细胞组成，每 50 个高倍视野有 2−3 个有丝分裂像。免疫组织化学显示，肿瘤细胞 CD117 (c-kit) 强阳性，CD34、SMA、s-100 蛋白和结蛋白阴性。从遗传学上来说，肿瘤在 PDGFRA 基因的外显子 18 密码子 824 GTC > GTT (V824V) [rs2228230] 处显示出沉默突变。术后 24 个月未发现复发。该病例使我们注意到在间叶性肿瘤（尤其是移植患者）的鉴别诊断中考虑 EGIST（包括 GIST）的重要性，尽管它们极为罕见。
The occurrence of de novo malignant neoplasms has been shown in post-transplant recipients receiving immunosuppressive treatment. We present a case of a rare extragastrointestinal stromal tumor (EGIST) located in the pelvic cavity of a kidney transplant patient. A 57-year-old female patient was admitted to our department because of non-specific lower abdominal pain 6 months after renal transplantation. An abdominal computed tomography scan showed a 4.5 cm diameter pelvic tumor mass. The tumor was resected en bloc and confirmed as not being connected to the gastrointestinal wall. Microscopically, the tumor consisted of typical spindle cells with 2−3 mitotic figures per 50 high-power fields. Immunohistochemically, the tumor cells were strongly positive for CD117 (c-kit), and negative for CD34, SMA, s-100 protein, and desmin. Genetically, the tumor showed a silent mutation in exon 18 of thePDGFRAgene at codon 824 GTC > GTT (V824V) [rs2228230]. No recurrence was noted 24 months after the operation. This case draws our attention to the importance of considering EGISTs (including GISTs), even though they are extremely uncommon, in the differential diagnosis of mesenchymal neoplasms, especially in transplant patients.
影响因子：
29.4
作者：
Hirota, S;Ohashi, A;Kitamura, Y
通讯作者：
Kitamura, Y