Rate of cerebral energy consumption in concussive head injury in the rat.
Rate of cerebral energy consumption in concussive head injury in the rat.
复制标题
大鼠脑震荡损伤时的脑能量消耗率。
作者：
B. Nilsson;C. Nordström
代谢率测定在大鼠脑中的即时震荡响应标准化的冲击加速度为7和9米/秒的速度。在一个系列中，在撞击后20秒，在冷冻夹持的皮质和脑干组织中确定代谢状态。根据10秒完全缺血期间邻近未夹紧组织中的能量消耗速率计算代谢速率。冷冻夹闭程序本身被证明可能通过诱导机械兴奋来提高代谢率。在另一个系列中，在相同情况下使用原位冷冻进行组织取样。10秒的心脏静止期诱导了标准化的缺血期。在以7 m/s速度撞击加速度的急性脑震荡反应期间，脑干中的代谢率增加。以9米/秒的速度更强烈的震荡冲击进一步增强了这种反应，也涉及皮层。它的结论是，即时脑震荡反应的基础是一个机械引起的神经元兴奋。这可能导致能量耗尽，除非增加的代谢需求得到满足。
The metabolic rate was determined in the rat brain during the immediate concussive response to standardized impact accelerations of 7 and 9 m/sec velocity. In one series, the metabolic state was determined in freeze-clamped cortical and brain-stem tissue 20 seconds after the impact. The metabolic rate was calculated from the rate of energy depletion in the adjacent unclamped tissue during 10 seconds of total ischemia. The freeze-clamping procedure per se was shown to enhance the metabolic rate probably by inducing mechanical excitation. In another series, in situ freezing was used for tissue sampling in the same situation. A 10-second period of heart standstill induced a standardized period of ischemia. During the acute concussive response to impact acceleration at 7 m/sec velocity, there was an increase of the metabolic rate in the brain stem. A more intense concussive impact at 9 m/sec velocity further enhanced this reaction and also involved the cortex. It is concluded that the basis of the immediate concussive response is a mechanically elicited neuronal excitation. This may lead to energy depletion unless the increased metabolic demands are met.