Innate Immune Cells in Immune Tolerance After Liver Transplantation.
Innate Immune Cells in Immune Tolerance After Liver Transplantation.
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肝移植后先天免疫细胞的免疫耐受
DOI：
10.3389/fimmu.2018.02401
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发表时间：
2018
影响因子：
7.3
通讯作者：
Xia Q
中科院分区：
文献类型：
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作者：
Huang H;Lu Y;Zhou T;Gu G;Xia Q
目前，肝移植是治疗终末期肝病最有效的方法。术后需服用免疫抑制剂，可显著降低排斥反应率，提高短期（<1年）生存率。然而，与免疫抑制治疗相关的移植后并发症导致了旨在保护肾功能和预防新发癌症和代谢异常综合征的新方案的开发。供者特异性免疫耐受是指受者成熟的免疫系统在无任何免疫抑制治疗的情况下不攻击移植物，被认为是肝移植后的最佳状态。有研究表明，部分患者在肝移植后可以达到这种免疫耐受状态。肝内免疫系统与其他实体器官的免疫系统有很大的不同，尤其是先天性免疫系统。肝内含有多种肝特异性细胞，如肝源性树突状细胞、枯否细胞、肝窦内皮细胞、肝源性自然杀伤（NK）细胞、自然杀伤T（NKT）细胞等，这些肝内天然免疫细胞以其独特的结构和功能在肝内免疫耐受的形成中发挥重要作用。本文就肝内天然免疫细胞诱导肝移植免疫耐受的分子机制进行综述，以期对肝脏的致耐受功能有更深入的认识。
Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immunosuppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to the immunosuppressive therapy have led to the development of new protocols aimed at protecting renal function and preventing de novo cancer and dysmetabolic syndrome. Donor specific immune tolerance, which means the mature immune systems of recipients will not attack the grafts under the conditions without any immunosuppression therapies, is considered the optimal state after liver transplantation. There have been studies that have shown that some patients can reach this immune tolerance state after liver transplantation. The intrahepatic immune system is quite different from that in other solid organs, especially the innate immune system. It contains a variety of liver specific cells, such as liver-derived dendritic cells, Kupffer cells, liver sinusoidal endothelial cells, liver-derived natural killer (NK) cells, natural killer T (NKT) cells, and so on. Depending on their specific structures and functions, these intrahepatic innate immune cells play important roles in the development of intrahepatic immune tolerance. In this article, in order to have a deeper understanding of the tolerogenic functions of liver, we summarized the molecular mechanisms of immune tolerance induced by intrahepatic innate immune cells after liver transplantation.
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影响因子：
32.4
作者：
Dong, HD;Zhu, GF;Chen, LP
通讯作者：
Chen, LP
影响因子：
15.9
作者：
Ikehara, Y;Yasunami, Y;Ikeda, S
通讯作者：
Ikeda, S
影响因子：
17.1
作者：
Bohne, Felix;Londono, Maria-Carlota;Sanchez-Fueyo, Alberto
通讯作者：
Sanchez-Fueyo, Alberto
影响因子：
2.2
作者：
Dai, Fu-Zhen;Yang, Jie;Xu, Ming-Qing
通讯作者：
Xu, Ming-Qing
影响因子：
30.5
作者：
通讯作者：
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