Overexpression of DIXDC1 correlates with enhanced cell growth and poor prognosis in human pancreatic ductal adenocarcinoma
Overexpression of DIXDC1 correlates with enhanced cell growth and poor prognosis in human pancreatic ductal adenocarcinoma
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DIXDC1 过度表达与人胰腺导管腺癌细胞生长增强和预后不良相关
DOI：
10.1016/j.humpath.2016.07.015
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发表时间：
2016-11-01
期刊：
影响因子：
3.3
通讯作者：
Wan, Chunhua
中科院分区：
文献类型：
--
作者：
Li, Xiaohong;Xiao, Ying;Wan, Chunhua
DIXDC 1是一种含有卷曲螺旋结构域和DIX结构域的蛋白质，参与多种癌症的进展。然而，DIXDC 1在人胰腺导管腺癌（PDAC）中的作用仍不清楚。在这项研究中，我们研究了DIXDC 1在人类PDAC发展中的作用和预后价值。Western blot分析显示DIXDC 1在PDAC组织和细胞系中高度表达。165例石蜡包埋切片的免疫组化显示，DIXDC 1的高表达与肿瘤大小（P =.002）、组织学分化（P =.001）、肿瘤淋巴结转移（TNM）分期（P =.001）和增殖标记物Ki-67（P =.000）显著相关。Kaplan-Meier分析显示，DIXDC 1高表达与总生存期恶化明显相关（P
Disheveled-axin (DIX) domain containing 1 (DIXDC1), a protein containing a coiled-coil domain and a DIX domain, is involved in the progression of multiple cancers. However, the role of DIXDC1 in human pancreatic ductal adenocarcinoma (PDAC) remains unclear. In this study, we investigated the role and prognostic value of DIXDC1 in the development of human PDAC. Western blot analysis revealed that DIXDC1 was highly expressed in PDAC tissues and cell lines. Immunohistochemistry on 165 paraffin-embedded sections showed that high expression of DIXDC1 was significantly correlated with tumor size (P =.002), histological differentiation (P =.001), tumor node metastasis (TNM) stage (P =.001), and the proliferation marker Ki-67 (P =.000). Importantly, Kaplan-Meier analysis revealed that high expression of DIXDC1 was obviously correlated with worsened overall survival (P