Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response
Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response
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DOI：
10.4049/jimmunol.174.12.8011
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发表时间：
2005-06-15
影响因子：
4.4
通讯作者：
Shen, H
中科院分区：
文献类型：
--
作者：
Zenewicz, LA;Wei, ZY;Shen, H
磷脂酰肌醇特异性磷脂酶（PI-PLC）是由包括炭疽芽孢杆菌和单核细胞增生李斯特菌在内的许多病原菌产生的毒力因子。芽孢杆菌属PI-PLC与李斯特菌属PI-PLC的不同之处在于其具有强的切割GPI锚定蛋白的活性。用芽孢杆菌而不是李斯特菌处理鼠DC，PI-PLC抑制TLR配体对树突状细胞（DC）的活化。用表达B的李斯特菌感染小鼠。炭疽杆菌PI-PLC导致Ag特异性CD 4 T细胞应答降低。这些数据表明，B.炭疽PI-PLC下调DC功能和T细胞反应，可能是通过切割对TLR介导的DC活化重要的GPI锚定蛋白。
Phosphatidylinositol-specific phospholipases (PI-PLCs) are virulence factors produced by many pathogenic bacteria, including Bacillus anthracis and Listeria monocytogenes. Bacillus PI-PLC differs from Listeria PI-PLC in that it has strong activity for cleaving GPI-anchored proteins. Treatment of murine DCs with Bacillus, but not Listeria, PI-PLC inhibited dendritic cell (DC) activation by TLR ligands. Infection of mice with Listeria expressing B. anthracis PI-PLC resulted in a reduced Ag-specific CD4 T cell response. These data indicate that B. anthracis PI-PLC down-modulates DC function and T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated DC activation.