Prognostic significance of etiological risk factors in early breast cancer
Prognostic significance of etiological risk factors in early breast cancer
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DOI：
10.1023/a:1005790531122
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发表时间：
1997-05-01
影响因子：
3.8
通讯作者：
Blijham, GH
中科院分区：
文献类型：
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作者：
Schouten, LJ;Hupperets, PSGJ;Blijham, GH
乳腺癌的病因学的几个危险因素也与乳腺癌的预后相关。然而，已发表的研究得出了相互矛盾的结果，71岁以下的I、II或III期乳腺癌妇女有资格入选临床研究。866例乳腺癌患者入组研究，其中463例淋巴结阳性，采用考克斯比例风险模型分析生存率。初潮年龄、产次、绝经年龄和家族史与生存率并不一致。第一次足月妊娠时年龄较小与生存率降低相关（校正相对危险度（RR）：1.69，95%置信区间（95% CI）：1.04-2.68），但不能排除该结果仅是由于偶然性所致。口服避孕药的使用与生存无关（RR：1.10，95%CI：0.80-1.51），家族史也与生存无关（RR：0.93，95%CI：0.66-1.30）。这项研究对乳腺癌危险因素与生存相关的假设几乎没有支持。
Several risk factors for the etiology of breast cancer have also been correlated with the prognosis of breast cancer. However, the published studies have yielded conflicting results.Women under 71 years of age with stage I, II, or III breast cancer were eligible for inclusion in a clinical study. 866 patients with breast cancer entered the study, of whom 463 had positive lymph nodes.Survival was analysed using Cox's proportional hazards model. Age at menarche, parity, age at menopause and family history were not consistently related to survival. Young age at first full-term pregnancy was related to decreased survival (adjusted relative risk (RR): 1.69, 95% confidence intervals (95% CI):1.04-2.68),but it cannot be excluded that this result was due to chance alone. Use of oral contraceptives was not correlated with survival (RR: 1.10, 95% CI: 0.80-1.51) nor was family history (RR: 0.93, 95% CI: 0.66-1.30).This study provided little support for the hypothesis that risk factors for breast cancer are related to survival.