Cutaneous larva migrans in travelers:: A prospective study, with assessment of therapy with ivermectin
Cutaneous larva migrans in travelers:: A prospective study, with assessment of therapy with ivermectin
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DOI：
10.1086/313942
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发表时间：
2000-08-01
影响因子：
11.8
通讯作者：
Coulaud, JP
中科院分区：
文献类型：
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作者：
Bouchaud, O;Houzé, S;Coulaud, JP
这项前瞻性研究的目的是更新皮肤幼虫迁徙(CLM)的流行病学数据，并评估伊维菌素的治疗效果。我们在1994年6月至1998年12月期间在我们的旅行诊所进行了这项研究。所有慢性粒细胞白血病患者均单剂量给予伊维菌素(200g/kg)，并通过问卷调查评价其疗效和耐受性。60名犯规患者入选。所有人都是欧洲人，都住在热带地区。在患者从目的地返回后，55%的患者在平均16天内发生皮损(7例患者1-120天；1个月)。55%的患者的初始诊断是错误的。病变个数1~15个，平均3个，主要部位为足部(48%)和臀部(23%)。单剂伊维菌素的治愈率为77%。14例患者需补充1~2剂，总治愈率为97%。瘙痒和皮损消失所需的中位时间分别为3天和7天。没有系统性不良反应的报道。医生对潜伏期较长的CLM的了解很差。单剂量伊维菌素疗法似乎有效且耐受性良好，即使有时需要几种治疗方法。
The purpose of this prospective study was to update epidemiological data on cutaneous larva migrans (CLM) and to assess the: therapeutic efficacy of ivermectin. We performed the study between June 1994 and December 1998 at our travel clinic. Ivermectin (a single dose of 200 g/kg) was offered to all the patients with CLM, and its efficacy and tolerability were assessed by a questionnaire. Sixty-fouls patients were enrolled. All were European and had stayed in tropical areas. After the patients had returned from their destinations, 55% had lesions occur within a mean of 16 days (range, 1-120 days; >1 month in 7 patients). The initial diagnosis was wrong in 55% of patients. The mean number of lesions was 3 (range, 1-15), and the main sites were the feet (48%) and buttocks (23%). The cure rate after a single dose of ivermectin was 77%. In 14 patients, 1 or 2 supplementary doses were necessary, and the overall cure rate was 97%. The median time required for pruritus and lesions to disappear was 3 and 7 days, respectively. No systemic adverse effects were reported. Physicians' knowledge of CLM, which can have a long incubation period, is poor. Single-dose ivermectin therapy appears to be effective and well tolerated, even if several treatments are sometimes necessary.