Tortuosity of the white matter medullary arterioles is related to the severity of hypertension
Tortuosity of the white matter medullary arterioles is related to the severity of hypertension
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DOI：
10.1159/000057850
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发表时间：
2002-01-01
影响因子：
2.9
通讯作者：
Oda, M
中科院分区：
文献类型：
--
作者：
Hiroki, M;Miyashita, K;Oda, M
背景：白质髓质小动脉迂曲的临床意义尚未明确阐明。我们定量研究了这种血管迂曲度与高血压（HT）严重程度之间的关系，高血压根据世界卫生组织分类进行分级。方法：对 47 个具有年龄调整 HT 阶段的尸检大脑进行了评估。通过光镜观察在放射冠和半卵圆中心水平测量同一迂曲病灶的最大迂曲直径和最大血管直径。计算每个患者的这些直径的最大比率。结果：在几乎所有小动脉中都发现了最大比率，并且根据 HT 阶段显着增加。结论：半球白质中的小动脉迂曲度可能反映了HT的严重程度，并且是脑部高血压性小血管疾病的一个指标。版权所有 (C) 2002 S. Karger AG，巴塞尔。
Background: The clinical implication of the tortuosity of white matter medullary arterioles has never been clarified precisely. We quantitatively investigated the relationship between such vascular tortuosity and the severity of hypertension (HT), which was graded according to the WHO classification. Methods: Forty-seven autopsied brains with age-adjusted stages of HT were evaluated. The largest tortuosity diameter and the largest vascular diameter in the same tortuous lesion were measured by light microscopic observation at the level of the corona radiata and centrum semiovale. A maximum ratio of these diameters was calculated for each patient. Results: Maximum ratios were found in almost all arterioles and were significantly increased according to the HT stages. Conclusions: Arteriolar tortuosity in the hemispheric white matter may reflect the severity of HT and be an indicator of hypertensive small vessel disease of the brain. Copyright (C) 2002 S. Karger AG, Basel.