The sodium/multivitamin transporter: a multipotent system with therapeutic implications.
The sodium/multivitamin transporter: a multipotent system with therapeutic implications.
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DOI：
10.1016/bs.vh.2014.12.003
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发表时间：
2015
影响因子：
--
通讯作者：
Shi L
中科院分区：
文献类型：
--
作者：
Quick M;Shi L
Na+/多种维生素转运蛋白（SMVT）是溶质：钠同向转运蛋白（SSS）家族的成员，催化结构多样的水溶性维生素泛酸（维生素B5）和生物素（维生素H）、α-硫辛酸（一种具有强抗氧化特性的维生素样物质）和碘化物的Na+依赖性摄取。SMVT的有机底物在细胞代谢中起核心作用，因此对正常人类健康和发育至关重要。例如，生物素缺乏导致生长迟缓、皮肤病和神经病。动物研究表明，妊娠期间生物素缺乏与胚胎生长迟缓、先天畸形和胚胎死亡直接相关。本章重点介绍了人类同种型SMVT（hSMVT）的结构和功能特征，该发现极大地促进了hSMVT在易处理的表达系统中的克隆和表达。特别强调的是hSMVT的运输过程中，将告知我们的动态背景下，以减轻开发和优化的hSMVT作为一个多能平台的药物输送的hSMVT介导的运输的分子决定因素的理解机制的影响。
The Na+/multivitamin transporter (SMVT) is a member of the Solute:Sodium Symporter (SSS) family, that catalyzes the Na+-dependent uptake of the structurally diverse water-soluble vitamins pantothenic acid (vitamin B5) and biotin (vitamin H), α-lipoic acid – a vitamin-like substance with strong anti-oxidant properties – and iodide. The organic substrates of SMVT play central roles in the cellular metabolism and are, therefore, essential for normal human health and development. For example, biotin deficiency leads to growth retardation, dermatological disorders, and neurological disorders. Animal studies have shown that biotin deficiency during pregnancy is directly correlated to embryonic growth retardation, congenital malformation, and death of the embryo. This chapter focuses on the structural and functional features of the human isoform of SMVT (hSMVT) the discovery of which was greatly facilitated by the cloning and expression of hSMVT in tractable expression systems. Special emphasis will be given to mechanistic implications of the transport process of hSMVT that will inform our understanding of the molecular determinants of hSMVT-mediated transport in dynamic context to alleviate the development and optimization of hSMVT as a multipotent platform for drug delivery.
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影响因子：
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作者：
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DOI：
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发表时间：
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