Differences in testicular development between 5α-reductase 2 deficiency and isolated bilateral cryptorchidism
Differences in testicular development between 5α-reductase 2 deficiency and isolated bilateral cryptorchidism
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DOI：
10.1016/j.juro.2008.05.063
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发表时间：
2008-09-01
影响因子：
6.6
通讯作者：
Dessouky, N.
中科院分区：
文献类型：
--
作者：
Hadziselimovic, F.;Dessouky, N.
目的：我们证明大多数类固醇 5 α-还原酶 2 缺乏症患者会出现不育症。材料和方法：我们将类固醇 5 α-还原酶 2 缺乏症男孩的睾丸组织病理学与孤立性双侧隐睾男孩的睾丸组织病理学进行比较。结果：类固醇 5 α-还原酶 2 缺乏症男孩的睾丸缺乏精母细胞，但具有 Ad 精原细胞和正常的生殖细胞计数。相反，双侧隐睾有严重的生殖细胞耗竭，并且大多数缺乏 Ad 精原细胞。结论：在类固醇 5 α-还原酶 2 缺乏的患者中，生殖细胞成熟的第二步受损，导致精原细胞向精母细胞的转化有缺陷。未降睾丸的位置似乎对类固醇 5a-还原酶 2 缺乏症患者的生殖细胞发育没有重大病理影响。
Purpose: We demonstrated that infertility develops in most patients with steroid 5 alpha-reductase 2 deficiency.Materials and Methods: We compared the testicular histopathology of boys with steroid 5 alpha-reductase 2 deficiency to that of boys with isolated bilateral cryptorchidism.Results: Testes with steroid 5 alpha-reductase 2 deficiency lacked spermatocytes but had Ad spermatogonia and a normal germ cell count. In contrast, bilateral cryptorchid testes had severe germ cell depletion and the majority lacked Ad spermatogonia.Conclusions: In patients with steroid 5 alpha-reductase 2 deficiency the impaired second step of germ cell maturation results in defective transformation of spermatogonia into spermatocytes. The position of the undescended testis appears to have no major pathological impact on the development of germ cells in patients with steroid 5a-reductase 2 deficiency.