ID: 202: IL-27 elicits responses similar to Interferon-gamma in non-hematopoietic cells
ID: 202: IL-27 elicits responses similar to Interferon-gamma in non-hematopoietic cells
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ID：202：IL-27 在非造血细胞中引发类似于干扰素-γ 的反应
DOI：
10.1016/j.cyto.2015.08.206
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发表时间：
--
期刊：
影响因子：
3.8
通讯作者：
C. Haan
中科院分区：
文献类型：
--
作者：
Rolvering;A. Zimmer;I. Behrmann;C. Haan
白细胞介素-27（IL-27）是主要由活化的巨噬细胞和树突状细胞分泌的I型细胞因子。最好的描述是IL-27对T细胞和先天免疫细胞的作用。虽然IL-27可以具有促炎作用，但许多研究也表明IL-27具有免疫抑制作用。IL-27由两个非共价连接的亚基p28和EBI 3（Epstein-Barr病毒诱导基因3）组成，并通过WSX-1和gp 130细胞因子受体进行信号传导;它可以被归类为IL-6/IL-12细胞因子超家族。当将IL-27的信号传导与IL-6型细胞因子（STAT 3主导的）和干扰素-γ（STAT 1主导的）之一时，我们观察到IL-27激发类似于干扰素-γ的应答。
Interleukin-27 (IL-27) is a type-I-cytokine predominantly secreted by activated macrophages and dendritic cells. Best described are the effects of IL-27 on T-cells and on innate immune cells. Although IL-27 can have pro-inflammatory effects, many studies also suggest that IL-27 is immunosuppressive. IL-27 is composed of the two non-covalently linked subunits p28 and EBI3 (Epstein-Barr virus induced gene 3) and signals via the WSX-1 and gp130 cytokine receptors; it can be grouped into the IL-6/IL-12 superfamily of cytokines.We here report that a variety of non-hematopoietic cells respond to IL-27. When comparing signaling of IL-27 to the one of IL-6-type cytokines (STAT3-dominated) and Interferon-gamma (STAT1-dominated), we observe that IL-27 elicits responses similar to Interferon-gamma.