Noninvasive localization of electromagnetic epileptic activity. II. Demonstration of sublobar accuracy in patients with simultaneous surface and depth recordings
Noninvasive localization of electromagnetic epileptic activity. II. Demonstration of sublobar accuracy in patients with simultaneous surface and depth recordings
复制标题
DOI：
10.1023/a:1012996930489
复制
发表时间：
2001-12-01
期刊：
影响因子：
2.7
通讯作者：
Michel, CM
中科院分区：
文献类型：
--
作者：
Lantz, G;Menendez, RGD;Michel, CM
7例复杂部分性癫痫发作患者接受侵入性视频/脑电图监测，研究了10个硬膜下条形电极触点（颞下+颞侧）和22个颅外记录部位的组合。在每个病人的棘波与不同的颅内分布进行了鉴定，并为那些具有相似的分布颅外活动的平均值。使用一种称为EPIFOCUS的新逆解方法（Grave等人，2001，本期）重建标准3D-MRI中单个和平均棘波的来源，并进行统计分析，以证明不同颅内分布的棘波之间的位置差异。结果显示，颞下区的前、腹源位置明显多于颞侧区。在颞下组，内侧棘波有更多的内侧和背侧的位置相比，外侧。在颞侧组，更多的前部和腹侧的位置获得前相比，后部的尖峰。结果表明，EPIFOCUS的适用性，在颞叶与sublobar精度的源定位。这种可能性在未来可能会变得很重要，例如在确定杏仁核-小脑半球切除术或其他有限的颞叶切除术可能取代标准整块切除术的情况下。
Seven patients with complex partial epileptic seizures undergoing invasive video/EEG-monitoring were investigated with a combination of 10 subdural strip electrode contacts (subtemporal + lateral temporal), and 22 extracranial recording sites. In each patient spikes with different intracranial distributions were identified, and for those with similar distributions the extracranial activity was averaged. A new inverse solution method called EPIFOCUS (Grave et al. 2001, this issue) was used to reconstruct the sources of both single and averaged spikes in a standard 3D-MRI, and a statistical analysis was performed in order to demonstrate location differences between spikes with different intracranial distributions. The results revealed significantly more anterior and ventral source locations for subtemporal compared to lateral temporal spikes. Within the subtemporal group, medial spikes had more mesial and dorsal locations compared to lateral ones. In the lateral temporal group, more anterior and ventral locations were obtained for anterior compared to posterior spikes. The results demonstrate the applicability of EPIFOCUS in the localization of sources in the temporal lobe with sublobar accuracy. This possibility may become important in the future, for instance in identifying cases where amygdalo-hippocampectomy or other limited temporal lobe resections may replace the standard en bloc resections.