Impact of cancer therapy on post‐treatment ejaculation disorder and sexual life in testicular cancer survivors
Impact of cancer therapy on post‐treatment ejaculation disorder and sexual life in testicular cancer survivors
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癌症治疗对睾丸癌幸存者治疗后射精障碍和性生活的影响
DOI：
10.1111/iju.14403
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发表时间：
2020
影响因子：
2.6
通讯作者：
Ito Akihiro
中科院分区：
文献类型：
--
作者：
Koyama Juntaro;Yamashita Shinichi;Yamada Shigeyuki;Fujii Shinji;Goto Takuro;Katayama Hiromichi;Satake Yohei;Sato Takuma;Shimada Shuichi;Kawasaki Yoshihide;Kawamorita Naoki;Mitsuzuka Koji;Arai Yoichi;Ito Akihiro
ObjectiveEvaluate the impact of cancer therapy on post-treatment ejaculation in patients with testicular cancer.MethodsA total 74 testicular cancer survivors provided completed International Index of Erectile Function-15 questionnaire before and after treatment between 2010 and 2017.治疗前后评估性功能，特别是射精功能。在这项研究中，对于9号问卷（射精频率）回答“1 =几乎从未/从未”或“2 =几次”的患者被定义为“射精障碍”。结果在74例睾丸癌幸存者中，50例（68%）在治疗前没有射精障碍。接受化疗和腹膜后淋巴结清扫术的9名幸存者中有4名（44%）在治疗后出现射精障碍。在多变量分析中，腹膜后淋巴结清扫术是治疗后射精障碍的重要预测因素（P= 0.042）。在60例治疗后射精功能可评估的患者中，24例（40%）未尝试性交，多因素分析显示射精障碍对性交有显著的负面影响（P= 0.035）。此外，治疗后有射精障碍组和无射精障碍组的平均国际勃起功能指数-15评分分别为24.0和51.9（P< 0.001）。许多睾丸癌幸存者报告没有性交射精障碍，这表明对性生活的不利影响。泌尿科医生应提供适当的咨询，关于射精障碍的风险及其对性生活的可能影响。
ObjectiveTo evaluate the impact of cancer therapy on post‐treatment ejaculation in patients with testicular cancer.MethodsA total of 74 testicular cancer survivors provided completed International Index of Erectile Function‐15 questionnaires before and after treatment between 2010 and 2017. Sexual function, particularly ejaculatory function, was evaluated before and after treatment. In this study, patients who answered “1 = almost never/never” or “2 = a few times” for questionnaire number 9 (ejaculation frequency) were defined as having “ejaculation disorder.”ResultsOf 74 testicular cancer survivors, 50 (68%) had no ejaculation disorders before treatment. Four (44%) of nine survivors, who received chemotherapy and retroperitoneal lymph node dissection, developed ejaculation disorders after treatment. On multivariate analysis, retroperitoneal lymph node dissection was a significant predictor of post‐treatment ejaculation disorder (P= 0.042). Of 60 survivors with evaluable ejaculation function after treatment, 24 (40%) did not attempt sexual intercourse, and multivariate analysis showed ejaculation disorder had a significant negative impact on having sexual intercourse (P= 0.035). Furthermore, the mean International Index of Erectile Function‐15 scores in the groups with and without ejaculation disorders after treatment were 24.0 and 51.9, respectively (P< 0.001).ConclusionEjaculation disorders occur at high rate after retroperitoneal lymph node dissection. Many testicular cancer survivors reporting no sexual intercourse have ejaculation disorders, suggesting an adverse impact on sexual life. Urologists should provide proper counselling regarding the risk of ejaculation disorder and its possible impact on sexual life.
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