Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections
Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections
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DOI：
10.1016/j.cyto.2004.06.005
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发表时间：
2004-10-07
期刊：
影响因子：
3.8
通讯作者：
Tonetti, MS
中科院分区：
文献类型：
--
作者：
D'Aiuto, F;Parkar, M;Tonetti, MS
对牙周炎等慢性感染的炎症反应可能是这些疾病的全身影响的中心。这项研究考察了严重全身性牙周炎患者中特定基因多态与全身炎症反应之间的可能联系。对94例牙周炎患者的IL-1A(-889)、IL-1B(-511，+3954)、肿瘤坏死因子-A(-308)、IL-6(-174)和TLR4(-299，-399)基因进行了基因分型。我们发现，在校正了年龄、体重指数、性别、种族和吸烟后，IL-1a或IL-6的基因型与血清IL-6(P<；0.03)和血清CRP(P<；0.05)的水平相关，同样，在校正了年龄、体重指数、性别、种族和吸烟后，TNF-A与血清IL-6的水平(P<；0.05)相关。严重牙周炎患者携带罕见的功能性炎症基因多态等位基因时，全身炎症反应较高。这些结果表明，细胞因子基因型别是牙周炎患者全身炎症反应的重要决定因素。因此，遗传多态可以部分解释已报道的牙周炎和系统性疾病之间的联系。(C)2004爱思唯尔有限公司。保留所有权利。
The inflammatory response to chronic infections such as periodontitis may be central to the systemic implications of these diseases. This study examined the possible association between specific gene polymorphisms and the systemic inflammatory response in individuals suffering from severe generalized periodontitis. Ninety-four subjects with periodontitis were genotyped for polymorphisms in IL-1A (-889), IL-1B (-511, +3954), TNF-A (-308), IL-6 (-174) and TLR4 (-299, -399) genes. We found that the genotypes for IL-1A or IL-6 are associated with higher levels of serum IL-6 (P < 0.03) and serum CRP (P < 0.05), similarly the TNF-A genotype is associated with higher levels of serum IL-6 (P < 0.05) after correction for age, body mass index, gender, ethnicity and cigarette smoking. Systemic inflammatory responses are higher in severe periodontitis patients carrying rare alleles for functional inflammatory gene polymorphisms. These results suggest that cytokine genotypes are important determinants of the systemic inflammatory response in subjects with periodontitis. Genetic polymorphism, therefore, may in part explain the reported association between periodontitis and systemic disease. (C) 2004 Elsevier Ltd. All rights reserved.