SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
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DOI：
10.1038/sj.cr.7290272
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发表时间：
2005-02-01
期刊：
影响因子：
44.1
通讯作者：
He, L
中科院分区：
文献类型：
--
作者：
Shi, YY;He, L
在基于多位点的复杂疾病的遗传关联研究中，人们一直在寻找一种有效的工具来分析标记间的连锁不平衡（LD）、单倍型分布和大量样本的多个卡方/p值。为了实现直接从原始数据中获得有意义的结果的目标，我们开发了一个强大的和用户友好的软件平台，具有一系列的工具，用于高效率的关联研究分析。该平台已通过多组真实的数据进行了良好的评价。
In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses of linkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large number of samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data, we developed a robust and user-friendly software platform with a series of tools for analysis in association study with high efficiency. The platform has been well evaluated by several sets of real data.