Cannabinoid modulation of corticolimbic activation to threat in trauma-exposed adults: a preliminary study.
Cannabinoid modulation of corticolimbic activation to threat in trauma-exposed adults: a preliminary study.
复制标题
大麻素调节皮质边缘激活对遭受创伤的成年人的威胁：一项初步研究。
DOI：
10.1007/s00213-020-05499-8
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发表时间：
2020
影响因子：
3.4
通讯作者：
Elrahal,Farrah
中科院分区：
文献类型：
--
作者：
Rabinak,ChristineA;Blanchette,Ashley;Zabik,NicoleL;Peters,Craig;Marusak,HilaryA;Iadipaolo,Allesandra;Elrahal,Farrah
过度的恐惧和焦虑，加上皮质边缘功能障碍，是压力和创伤相关的精神病理学的核心特征，如创伤后应激障碍（PTSD）。有趣的是，低剂量的1，9-四氢大麻酚（THC）可以产生抗焦虑作用，减少威胁相关的杏仁核激活，并增强杏仁核和内侧前额叶皮层和相邻的喙扣带皮层（mPFC/rACC）之间的功能耦合在健康成年人的威胁处理。总之，这些发现表明大麻素系统是治疗过度恐惧和焦虑的潜在药理学靶点。然而，THC对皮质边缘功能的影响，以应对威胁尚未调查在成人与创伤相关的psychopathology.ObjectiveTo弥补这一差距，本研究测试了急性低剂量的THC对皮质边缘反应的影响，以威胁在三组成年人：（1）非创伤暴露的健康对照（HC;n= 25），（2）无PTSD的创伤暴露成人（TEC;方法采用随机、双盲、安慰剂对照、受试者间设计，71名参与者被随机分配接受THC或安慰剂（PBO），随后在功能性磁共振成像期间完成了一个完善的威胁处理范式。THC降低了威胁相关的杏仁核反应，增加mPFC激活过程中的威胁，并增加mPFC-杏仁核功能coupling.ConclusionsThese初步数据表明，THC调制的创伤暴露个体与PTSD，这可能被证明是有利的治疗压力和创伤相关的精神病理学的药理学方法的威胁相关的处理。
RationaleExcessive fear and anxiety, coupled with corticolimbic dysfunction, are core features of stress- and trauma-related psychopathology, such as posttraumatic stress disorder (PTSD). Interestingly, low doses of ∆9-tetrahydrocannabinol (THC) can produce anxiolytic effects, reduce threat-related amygdala activation, and enhance functional coupling between the amygdala and medial prefrontal cortex and adjacent rostral cingulate cortex (mPFC/rACC) during threat processing in healthy adults. Together, these findings suggest the cannabinoid system as a potential pharmacological target in the treatment of excess fear and anxiety. However, the effects of THC on corticolimbic functioning in response to threat have not be investigated in adults with trauma-related psychopathology.ObjectiveTo address this gap, the present study tests the effects of an acute low dose of THC on corticolimbic responses to threat in three groups of adults: (1) non-trauma-exposed healthy controls (HC;n= 25), (2) trauma-exposed adults without PTSD (TEC;n= 27), and (3) trauma-exposed adults with PTSD (n= 19).MethodsUsing a randomized, double-blind, placebo-controlled, between-subjects design, 71 participants were randomly assigned to receive either THC or placebo (PBO) and subsequently completed a well-established threat processing paradigm during functional magnetic resonance imaging.ResultsIn adults with PTSD, THC lowered threat-related amygdala reactivity, increased mPFC activation during threat, and increased mPFC-amygdala functional coupling.ConclusionsThese preliminary data suggest that THC modulates threat-related processing in trauma-exposed individuals with PTSD, which may prove advantageous as a pharmacological approach to treating stress- and trauma-related psychopathology.