CERTAIN PHARMACOLOGICAL CHARACTERISTICS OF RELEASE OF PANCREATIC GLUCAGON IN RESPONSE TO STIMULATION OF SPLANCHNIC NERVES
CERTAIN PHARMACOLOGICAL CHARACTERISTICS OF RELEASE OF PANCREATIC GLUCAGON IN RESPONSE TO STIMULATION OF SPLANCHNIC NERVES
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DOI：
10.1113/jphysiol.1978.sp012370
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发表时间：
1978-01-01
影响因子：
5.5
通讯作者：
EDWARDS, AV
中科院分区：
文献类型：
--
作者：
BLOOM, SR;EDWARDS, AV
α-β的影响和β-在出生后3-5周切除肾上腺的小牛中检测了肾上腺素受体阻断对胰腺胰高血糖素释放的反应，以响应内脏神经的外周末端的刺激。在肾上腺切除的狗中评估胰岛素、阿托品和生长抑素对胰高血糖素对内脏神经刺激的反应的影响。在小牛中，响应内脏神经刺激的胰高血糖素的释放不被有效消除α-谷氨酰胺的剂量的酚妥拉明抑制。肾上腺素能抑制胰岛素释放，或普萘洛尔，在剂量完全消除心脏交感神经支配的变时作用。在狗中，在引起循环血浆中胃泌素浓度稳定下降的剂量（0.5 μ g/kg）下，阿托品（0.2 mg/kg）或生长抑素不抑制响应内脏神经刺激的胰高血糖素释放。kg-1. min ~（-1）。外源性胰岛素（4.0 U[单位]/kg）明显增强胰高血糖素释放。讨论的结果与其他工人的调查结果。刺激胰腺交感神经支配导致胰高血糖素分泌的确切机制值得更详细的研究。
The effect of .alpha.- and .beta.-adrenoceptor blockade on the release of pancreatic glucagon, in response to stimulation of the peripheral ends of the splanchnic nerves, was examined in adrenalectomized calves 3-5 wk after birth. The effects of insulin, atropine and somatostatin on the glucagon response to splanchnic nerve stimulation were assessed in adrenalectomized dogs. In calves, release of pancreatic glucagon in response to splanchnic nerve stimulation was not suppressed by phentolamine at a dose that effectively abolished .alpha.-adrenergic inhibition of insulin release, or by propranolol, at a dose that completely eliminated the chronotropic action of the cardiac sympathetic innervation. In dogs, release of pancreatic glucagon in response to splanchnic nerve stimulation was not suppressed by atropine (0.2 mg/kg) or somatostatin, at a dose that caused a steady fall in the concentration of gastrin in the circulating plasma (0.5 .mu.g .cntdot. kg-1 .cntdot. min-1). Glucagon release was apparently potentiated by exogenous insulin (4.0 u[units]/kg). The results are discussed in relation to the findings of other workers. The precise mechanism whereby stimulation of the sympathetic innervation to the pancreas leads to secretion of glucagon merits more detailed investigation.