New Phenanthrenes and Stilbenes from Dendrobium loddigesii
New Phenanthrenes and Stilbenes from Dendrobium loddigesii
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DOI：
10.1248/cpb.58.628
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发表时间：
2010-05-01
影响因子：
1.7
通讯作者：
Kitanaka, Susumu
中科院分区：
文献类型：
--
作者：
Ito, Masanobu;Matsuzaki, Keiichi;Kitanaka, Susumu
从圆叶石斛（Dendrobium loddellisii ROLFE）沿着的80%乙醇提取物中分离得到新的菲类化合物，分别命名为圆叶石斛醇A（1）和B（7），圆叶石斛醇C（8）和D（9），同时还分离得到5个菲类化合物，3个二苯乙烯类化合物，2个木脂素类化合物和3个甾醇类化合物。它们的结构通过光谱研究确定。评价了这些化合物对一氧化氮（NO）产生的抑制活性和对2，2-二苯基-1-苦基肼基（DPPH）自由基的清除活性。菲（1-3，7）和二氢菲（4-6）对NO的生成有明显的抑制作用。特别地，2显示出比5和6更强的对NO产生的抑制活性。这表明该菲是比二氢菲更强的NO生成抑制剂。新的菲类化合物，碘甲烯醇A（1）和B（7），显著抑制NO的产生，IC 50值分别为2.6和10.9 μ M。一种新的二氢芪类化合物loddensiinol D（9）对NO的产生显示出较弱的抑制活性，IC 50值为69.7 μ M，但另一种新的二氢芪类化合物loddensiinol C（8）在100 μ M时没有显示出这种活性。
New phenanthrenes, loddigesiinols A (1) and B (7), and stilbenes, loddigesiinols C (8) and D (9), were isolated from 80% ethanol extract of Dendrobium loddigesii ROLFE (Orcharedceae) along with known compounds, including five phenanthrenes, three stilbenes, two lignans, and three sterols. Their structures were determined by spectroscopic studies. These compounds were evaluated for their inhibitory activities against nitric oxide (NO) production and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Phenanthrenes (1-3, 7) and dihydrophenanthrenes (4-6) showed significant inhibitory activity against NO production. In particular, 2 showed stronger inhibitory activity against NO production than 5 and 6. This suggested that this phenanthrene is a stronger inhibitor of NO production than dihydrophenanthrene. The new phenanthrenes, loddigesiinols A (1) and B (7), significantly inhibited NO production with IC50 values of 2.6 and 10.9 mu M, respectively. One new dihydrostilbene, loddigesiinol D (9), showed weak inhibitory activity against NO production with an IC50 value of 69.7 mu M, but the other new dihydrostilbene, loddigesiinol C (8), did not show this activity at 100 mu M.