Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis.
Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis.
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综述：中性粒细胞胞外陷阱在脓毒症及脓毒症相关血栓形成中的新兴作用
DOI：
10.3389/fcimb.2021.653228
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发表时间：
2021
影响因子：
5.7
通讯作者：
Miao C
中科院分区：
文献类型：
--
作者：
Chen Z;Zhang H;Qu M;Nan K;Cao H;Cata JP;Chen W;Miao C
脓毒症患者常发生凝血功能障碍，导致血栓形成。在脓毒症的发展过程中，中性粒细胞从循环血液迁移到感染的组织，并介导形成杀死病原体的中性粒细胞胞外陷阱（NET）。但中性粒细胞的过度活化可促进免疫血栓形成，甚至引起弥散性血管内凝血（DIC），损害微循环。脓毒症的预后取决于早期识别和干预，因此临床评估NETs功能可能是脓毒症早期诊断的有价值的生物标志物。NET与血小板、补体和内皮的相互作用介导脓毒症中免疫血栓形成。抑制NET的形成也被认为是脓毒症的潜在治疗方法之一。本文就中性粒细胞和NETs在脓毒症及脓毒症血栓形成中的作用进行综述，以期为脓毒症血栓治疗提供新的机制。
Patients with sepsis commonly suffer from coagulation dysfunction and lead to the formation of thrombus. During the development of sepsis, neutrophils migrate from the circulating blood to infected tissues and mediate the formation of neutrophil extracellular traps (NETs) that kill pathogens. However, the overactivation of neutrophils can promote the formation of immunothrombosis and even cause disseminated intravascular coagulation (DIC), which damages microcirculation. The outcome of sepsis depends on early recognition and intervention, so clinical evaluation of NETs function may be a valuable biomarker for early diagnosis of sepsis. The interaction of NETs with platelets, complement, and endothelium mediates the formation of immunothrombosis in sepsis. Inhibiting the formation of NETs is also considered to be one of the potential treatments for sepsis. In this review, we will discuss the key role of neutrophils and NETs in sepsis and septic thrombosis, in order to reveal new mechanisms for thrombosis treatment of sepsis.