Remodeling of vascular endothelial cells exposed to fluid shear stress: experimental and numerical approach
Remodeling of vascular endothelial cells exposed to fluid shear stress: experimental and numerical approach
复制标题
DOI：
10.1016/j.fluiddyn.2004.08.005
复制
发表时间：
2005-07
影响因子：
1.5
通讯作者：
T. Ohashi;Masaaki Sato
中科院分区：
文献类型：
--
作者：
T. Ohashi;Masaaki Sato
血管内皮细胞是血管壁与血流之间的界面，在生理功能中起重要作用。由于内皮细胞对流体剪切应力的反应与动脉粥样硬化的定位有关，因此专门研究了剪切应力对内皮细胞形态和功能的影响。在施加流体剪切应力后，培养的内皮细胞显示出明显的伸长和在流动方向上的取向。此外，肌动蛋白丝的粗应力纤维出现并沿细胞长轴沿着。因此，内皮细胞的形态与细胞骨架结构密切相关。本文综述了近年来内皮细胞对流体流动的反应，重点介绍了细胞形态和细胞骨架结构的变化。在细胞水平上模拟局部流场和由此产生的细胞内应力的数值研究也进行了审查。
Vascular endothelial cells are an interface between blood vessel walls and blood flow, and play important roles in physiological functions. Since endothelial cell responses to fluid shear stress have been implicated in the localization of atherosclerosis, the effect of shear stress on endothelial cell morphology and functions has been exclusively studied. After applying fluid shear stress, cultured endothelial cells show marked elongation and orientation in the flow direction. In addition, thick stress fibers of actin filaments appear and align along the cell long axis. Thus, the endothelial cell morphology is closely related to the cytoskeletal structure. The purpose of this review is to summarize endothelial cell responses to fluid flow which have been studied, focusing on the changes in cell shape and cytoskeletal structure. Numerical studies to simulate local flow field at the cellular level and the resulting intracellular stresses are also reviewed.