Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology
Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology
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DOI：
10.1182/blood-2009-05-219915
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发表时间：
2009-10-01
期刊：
影响因子：
20.3
通讯作者：
Heckbert, Susan R.
中科院分区：
文献类型：
--
作者：
Cushman, Mary;O'Meara, Ellen S.;Heckbert, Susan R.
高水平的促凝血因子和因子XII缺乏可能是首次静脉血栓栓塞症（VTE）的危险因素。我们在2个普通人群样本中研究了凝血因子IX至XIII与未来静脉血栓栓塞风险的关系。使用巢式病例对照研究，结合了21 860名参与者的动脉粥样硬化风险的社区研究和心血管健康研究，我们确定了这些凝血因子的抗原水平，主要是在事件发生前的血液样本，从462名参与者谁随后发展静脉血栓栓塞和1047名参与者谁保持自由静脉血栓栓塞。在调整年龄、性别、种族和研究后，只有因子IX和XI水平升高与VTE风险增加相关。对于因子IX，比较顶部与底部五分位数的比值比（OR）为1.4（95%置信区间[CI]，1.0-2.0）。因子XI的OR较高：2.0（95% CI，1.4-2.9）。进一步校正体重指数和糖尿病后，只有因子XI升高仍与VTE风险相关：OR 1.8（95%CI，1.3-2.7）。无论血栓形成是特发性的还是继发性的，研究的相关性都是相似的。因子XII缺乏与VTE风险无关。在这些促凝血因子中，只有因子XI升高是VTE的危险因素。（血。2009; 114：2878-2883）
Higher levels of procoagulant factors and factor XII deficiency may be risk factors for first venous thromboembolism (VTE). We studied associations of coagulation factors IX through XIII with risk of future VTE in 2 general population samples. Using a nested case-control study combining the 21 860 participants of the Atherosclerosis Risk in Communities study and the Cardiovascular Health Study, we determined antigenic levels of these co-agulation factors in primarily pre-event blood samples from 462 participants who subsequently developed VTE and 1047 participants who remained free of VTE. Only elevated levels of factors IX and XI were associated with increased risk of VTE after adjustment for age, sex, race, and study. For factor IX, the odds ratio (OR) was 1.4 (95% confidence interval [CI], 1.0-2.0) comparing the top to bottom quintile. The OR for factor XI was higher: 2.0 (95% CI, 1.4-2.9). With further adjustment for body mass index and diabetes, only elevated factor XI remained associated with VTE risk: OR 1.8 (95% CI, 1.3-2.7). Associations were similar by study and whether the thrombosis was idiopathic or secondary. Factor XII deficiency was not related to VTE risk. Among these procoagulant factors, only elevated factor XI was a risk factor for VTE. (Blood. 2009; 114: 2878-2883)