Ca2+-dependent modulation of voltage-gated Ca2+ channels.
Ca2+-dependent modulation of voltage-gated Ca2+ channels.
复制标题
DOI：
10.1016/j.bbagen.2011.12.012
复制
发表时间：
2012-08
影响因子：
3
通讯作者：
Lee, Amy
中科院分区：
文献类型：
--
作者：
Christel, Carl;Lee, Amy
电压门控（Cav）Ca 2+通道是一种多亚基复合体，在多种组织中发挥着不同的作用。控制Cav通道功能的基本机制涉及渗透通道孔的Ca 2+离子。Ca 2+内流通过Cav通道介导对通道的反馈调节，该反馈调节是负的（Ca 2+依赖性失活，CDI）和正的（Ca 2+依赖性易化，CDF）。这篇综述强调了CDI和CDF的一般机制，重点是如何在天然和异源表达系统中对这些过程进行电生理学研究。电生理学分析已经导致对CDI和CDF作为Cav通道调节机制的机制和流行的详细见解。所有Cav通道家族成员都经历依赖于CaM或相关Ca 2+结合蛋白的某种形式的Ca 2+依赖性反馈。在描述CaM在CDI和CDF中的作用方面取得了巨大进展。然而，是什么导致了CDI/CDF在各种细胞类型中的异质性以及Cav通道的Ca 2+依赖性调节如何控制Ca 2+信号传导仍然在很大程度上未被探索。Cav通道的Ca ~（2+）内流调控着肌肉兴奋-收缩偶联、神经递质和激素释放以及Ca ~（2+）依赖性基因转录等多种生理事件。因此，调节通道的机制，如CDI和CDF，可以在各种生理环境中对可兴奋细胞的信号传导潜力产生很大影响。
Voltage-gated (Cav) Ca2+ channels are multi-subunit complexes that play diverse roles in a wide variety of tissues. A fundamental mechanism controlling Cav channel function involves the Ca2+ ions that permeate the channel pore. Ca2+ influx through Cav channels mediates feedback regulation to the channel that is both negative (Ca2+-dependent inactivation, CDI) and positive (Ca2+-dependent facilitation, CDF). This review highlights general mechanisms of CDI and CDF with an emphasis on how these processes have been studied electrophysiologically in native and heterologous expression systems. Electrophysiological analyses have led to detailed insights into the mechanisms and prevalence of CDI and CDF as Cav channel regulatory mechanisms. All Cav channel family members undergo some form of Ca2+-dependent feedback that relies on CaM or a related Ca2+ binding protein. Tremendous progress has been made in characterizing the role of CaM in CDI and CDF. Yet, what contributes to the heterogeneity of CDI/CDF in various cell-types and how Ca2+-dependent regulation of Cav channels controls Ca2+ signaling remain largely unexplored. Ca2+ influx through Cav channels regulates diverse physiological events including excitation-contraction coupling in muscle, neurotransmitter and hormone release, and Ca2+-dependent gene transcription. Therefore, the mechanisms that regulate channels, such as CDI and CDF, can have a large impact on the signaling potential of excitable cells in various physiological contexts.
登录
查看更多内容
影响因子：
3.8
作者：
Bannister, Roger A.;Pessah, Isaac N.;Beam, Kurt G.
通讯作者：
Beam, Kurt G.
DOI：
10.1073/pnas.262372999
发表时间：
2002-12-24
影响因子：
11.1
作者：
Alseikhan, BA;DeMaria, CD;Yue, DT
通讯作者：
Yue, DT
影响因子：
5.3
作者：
Chaudhuri, D;Chang, SY;Yue, DT
通讯作者：
Yue, DT
影响因子：
21.1
作者：
Catterall, WA;Striessnig, J;Perez-Reyes, E
通讯作者：
Perez-Reyes, E
影响因子：
3.5
作者：
Cens, T;Mangoni, ME;Charnet, P
通讯作者：
Charnet, P