Sensitivity of MRI versus conventional screening in the diagnosis of BRCA-associated breast cancer in a national prospective series
Sensitivity of MRI versus conventional screening in the diagnosis of BRCA-associated breast cancer in a national prospective series
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DOI：
10.1016/j.breast.2007.01.006
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发表时间：
2007-08-01
期刊：
影响因子：
3.9
通讯作者：
Moller, Pal
中科院分区：
文献类型：
--
作者：
Hagen, Anne I.;Kvistad, Kjell Arne;Moller, Pal
我们想要比较乳腺磁共振成像(MRI)和传统的由乳房X线摄影(XRM)+/-超声组成的筛查程序在BRCA1/2突变携带者早期诊断乳腺癌的敏感性。对BRCA1/2突变携带者进行前瞻性的乳腺MRI和XRM+/-超声检查，对445例BRCA1突变携带者和46例BRCA2突变携带者进行867次MRI检查。共观察到25例癌症，其中5例(20%)为间歇性癌。诊断时，MRI检出肿瘤的敏感性为19/22=86%，XRM为12/24=50%。其中21人在诊断时进行了两种方法的检查。在19例BRCA1突变携带者中，MRI诊断DCIS的敏感性为1/3(33%)，对浸润性癌的敏感性为15/16(94%)。XRM对DCIS的敏感性为1/3(33%)，对pT1b为3/7(42%)，对pT1c为3/6(50%)，对pt2为3/3/100%。在两个BRCA2突变携带者中，乳腺MRI都显示出，但XRM都没有检测到。与XRM相比，乳腺MRI对诊断所有分期低于pt2的癌症具有更高的敏感性。(C)2007爱思唯尔有限公司。保留所有权利。
We wanted to compare the sensitivities of breast magnetic resonance imaging (MRI) and the conventional screening programme consisting of mammography (XRM) +/- ultrasound for early diagnosis of breast cancer in BRCA1/2 mutation carriers. BRCA1/2 mutation carriers were examined prospectively by both breast MRI and XRM +/- ultrasound.Eight hundred and sixty-seven MRI examinations were carried out in 445 BRCA1 and 46 BRCA2 mutation carriers. A total of 25 cancers were observed, five (20%) as interval cancers. At the time of diagnosis, sensitivity to detect cancer was 19/22 = 86% for MRI and 12/24 = 50% for XRM. Twenty-one were examined by both methods at the time of diagnosis. In the 19 BRCA1 mutation carriers among them, MRI had a sensitivity of 1/3(33%) to diagnose DCIS and 15/16 (94%) among the invasive cancers. For XRM the sensitivities were 1/3(33%) for DCIS, 3/7(42%) for pT1b, 3/6(50%) for pT1c, and 3/3/100%) for pT2. In the two BRCA2 mutation carriers, both were demonstrated by breast MRI, neither was detected by XRM.Breast MRI had increased sensitivity compared to XRM to diagnose all cancers staged less than pT2. (C) 2007 Elsevier Ltd. All rights reserved.