Architectural and Functional Commonalities between Enhancers and Promoters.
Architectural and Functional Commonalities between Enhancers and Promoters.
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DOI：
10.1016/j.cell.2015.08.008
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发表时间：
2015-08-27
期刊：
影响因子：
64.5
通讯作者：
Shiekhattar R
中科院分区：
文献类型：
--
作者：
Kim TK;Shiekhattar R
随着全基因组范围内转录调控研究的激增，增强子和启动子的传统定义需要重新审视。这些控制元件现在可以根据它们的局部和区域结构、它们的调节组分（包括组蛋白修饰和相关的结合因子）以及它们对转录的功能贡献来表征。这篇综述讨论了启动子和增强子在转录调控机制中的统一主题。
With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components including histone modifications and associated binding factors and their functional contribution to transcription. This review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.