Trends in treatment patterns and outcomes for DCIS patients: A SEER population-based analysis.
Trends in treatment patterns and outcomes for DCIS patients: A SEER population-based analysis.
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DCIS 患者的治疗模式和结果趋势：基于 SEER 人群的分析。
DOI：
10.1200/jco.2014.32.15_suppl.1007
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发表时间：
2014
影响因子：
45.3
通讯作者：
Shelley Hwang
中科院分区：
文献类型：
--
作者：
M. Worni;R. Greenup;Aimee Mackey;I. Akushevich;Shelley Hwang
1007 背景：导管原位癌 (DCIS) 被认为是乳腺浸润性导管癌的前兆病变，目前的治疗旨在防止进展为浸润性疾病。然而，当代治疗方案对乳腺癌生存的影响仍然不明确。方法：查询 1991 年至 2010 年 DCIS 患者的监测、流行病学和最终结果 (SEER) 登记。计算年龄调整后的发病率，并使用 Cochran Armitage 趋势检验分析治疗模式的趋势。生存分析采用针对癌症特异性的逆概率权重 (IPW) 调整竞争风险分析 (CSS) 和针对总生存 (OS) 的 Cox 比例风险回归分析。结果：121,080 名 DCIS 患者纳入分析。年龄调整后的发病率从1992年的23.2/10万女性增加到2010年的36.4/10万女性。2010年60-79岁女性的发病率最高(83.8/10万)。大多数患者我们...
1007 Background: Ductal carcinoma in situ (DCIS) is considered a precursor lesion of invasive ductal cancer of the breast, and current therapy aims to prevent progression to invasive disease. However, the impact of contemporary treatment options on breast-cancer survival remains poorly defined. Methods: The Surveillance, Epidemiology, and End Results (SEER) registry was queried from 1991-2010 for patients with DCIS. Age-adjusted incidence rates were calculated, and trends in treatment patterns were analysed using the Cochran Armitage trend test. Survival analyses were performed with inverse probability weight (IPW) adjusted competing risk analysis for cancer specific (CSS) and cox proportional hazard regression analysis for overall survival (OS). Results: 121,080 DCIS patients were included in the analysis. Age-adjusted incidence rates increased from 23.2/100,000 females in 1992 to 36.4/100,000 in 2010. Highest incidence rate was found among females age 60-79 years in 2010 (83.8/100,000). Most patients we...