The Contraceptive Sponge's Protection Against Chlamydia trachomatis and Neisseria gonorrhoeae
The Contraceptive Sponge's Protection Against Chlamydia trachomatis and Neisseria gonorrhoeae
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避孕海绵对沙眼衣原体和淋病奈瑟菌的防护作用
DOI：
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发表时间：
1987
影响因子：
3.1
通讯作者：
W. Sawasdivorn
中科院分区：
文献类型：
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作者：
M. Rosenberg;P. Feldblum;W. Sawasdivorn
为了调查避孕海绵对性传播疾病发病率的影响，我们在泰国曼谷的高危女性人群中进行了一项临床试验。 255 名女性被随机分配使用或不使用海绵，并每周进行一次淋病和衣原体感染评估。通过逻辑回归对潜在混杂因素进行调整后，与不使用海绵的女性相比，使用海绵的女性患衣原体感染（比值比 [OR]，0.6；90% 置信区间 [CI]，0.4-1.0）和淋病（OR，0.9；CI，0.6-1.3）的可能性较小。这些估计可能低估了保护程度，因为在该研究的试点阶段一些暴露被错误分类。这些结果与其他研究一致，表明杀精剂可以预防淋病，并且还可以预防一种更严重的公共卫生问题——沙眼衣原体。
To investigate the effect of the contraceptive sponge on the incidence of sexually transmitted diseases, we conducted a clinical trial among a high-risk population of women in Bangkok, Thailand. Two hundred fifty-five women were randomly assigned either to use the sponge or not and were evaluated weekly for gonorrhea and chlamydial infection. After adjustment by logistic regression for potentially confounding factors, women using the sponge were less likely to have contracted chlamydial infection (odds ratio [OR], 0.6; 90% confidence interval [CI], 0.4-1.0) and gonorrhea (OR, 0.9; CI, 0.6-1.3) as compared with women not using the sponge. These estimates probably underestimate the degree of protection because some exposure was misclassified in this pilot phase of the study. These results are consistent with other studies indicating that spermicides protect against gonorrhea and also demonstrating protection against an organism of even greater public health concern, Chlamydia trachomatis.