MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma.
MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma.
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MicroRNA-23b 作为癌基因发挥作用，并通过靶向肝细胞癌中的 ST7L 激活 AKT/GSK3 beta/beta-catenin 信号传导
DOI：
10.1038/cddis.2017.216
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发表时间：
2017-05-18
影响因子：
9
通讯作者：
Wu L
中科院分区：
文献类型：
--
作者：
Zhuang L;Wang X;Wang Z;Ma X;Han B;Zou H;Wu Z;Dong S;Qu Z;Zang Y;Wu L
Hepatocellular carcinoma (HCC) is a malignant tumor and threatens human life worldwide, whereas the etiology and pathogenesis of HCC have not been fully determined. In the past few years, many microRNAs (miRNAs) have been proved to have important roles in tumorigenesis of HCC. In this study, we found that miR-23b was significantly upregulated in tumor tissues of HCC patients. Functional tests showed that miR-23b could promote HCC cell proliferation and metastasis in vitro and in vivo. Then, mechanistic investigations suggested that ST7L was a direct target of miR-23b and involved in the promotion effects of miR-23b on HCC tumorigenesis and metastasis. Furthermore, our study indicated that ST7L could interact with the carboxyl terminal region of AKT and suppress AKT/GSK3β/β-catenin pathway in HCC cells. In conclusion, our study revealed important roles of miR-23b and ST7L in progression of HCC.
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影响因子：
6.4
作者：
Huang, Shenglin;He, Xianghuo;Gu, Jianren
通讯作者：
Gu, Jianren
影响因子：
9
作者：
Zhuang LK;Yang YT;Ma X;Han B;Wang ZS;Zhao QY;Wu LQ;Qu ZQ
通讯作者：
Qu ZQ
影响因子：
3.7
作者：
Majid S;Dar AA;Saini S;Deng G;Chang I;Greene K;Tanaka Y;Dahiya R;Yamamura S
通讯作者：
Yamamura S
miR-23b-3p通过靶向ATG12和HMGB2调节胃癌细胞的化疗耐药
影响因子：
9
作者：
An Y;Zhang Z;Shang Y;Jiang X;Dong J;Yu P;Nie Y;Zhao Q
通讯作者：
Zhao Q
DOI：
10.1016/j.bbrc.2016.06.077
发表时间：
2016-09-02
影响因子：
3.1
作者：
Park, Na Ri;Cha, Jung Hoon;Yoon, Seung Kew
通讯作者：
Yoon, Seung Kew