The cerebellum contributes to somatosensory cortical activity during self-produced tactile stimulation
The cerebellum contributes to somatosensory cortical activity during self-produced tactile stimulation
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DOI：
10.1006/nimg.1999.0478
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发表时间：
1999-10-01
期刊：
影响因子：
5.7
通讯作者：
Frith, CD
中科院分区：
文献类型：
--
作者：
Blakemore, SJ;Wolpert, DM;Frith, CD
我们使用功能磁共振成像来检查受试者在经历自我产生或外部产生的触觉刺激时的神经反应。当外部刺激产生时，躯体感觉皮层的活动水平会增加。在小脑中，与产生触觉刺激的运动相比，与产生触觉刺激的运动相关的活动较少。这种差异表明，小脑参与预测运动的特定感觉结果，并提供用于减弱对自我产生的刺激的感觉反应的信号。在本文中，我们使用回归分析来测试这一假设明确。具体来说，我们预测小脑的活动有助于减少体感皮层活动在自我产生的触觉刺激。支持这一假设的证据是通过证明当触觉刺激是自我产生的而不是外部产生的时，丘脑和初级和次级躯体感觉皮层的活动显着回归小脑的活动而获得的。这支持了小脑参与预测运动的感觉结果的提议。在本研究中，这一预测是准确的，当触觉刺激是相对于它们是外部产生的，因此被用来衰减体感反应的前一种类型的触觉刺激，但不是后者。(C)北京：科学出版社.
We used fMRI to examine neural responses when subjects experienced a tactile stimulus that was either self-produced or externally produced. The somatosensory cortex showed increased levels of activity when the stimulus was externally produced. In the cerebellum there was less activity associated with, a movement that generated a tactile stimulus than with a movement that did not. This difference suggests that the cerebellum is involved in predicting the specific sensory consequences of movements and providing the signal that is used to attenuate the sensory response to self-generated stimulation. In this paper, we use regression analyses to test this hypothesis explicitly. Specifically, we predicted that activity in the cerebellum contributes to the decrease in somatosensory cortex activity during self-produced tactile stimulation. Evidence in favor of this hypothesis was obtained by demonstrating that activity in the thalamus and primary and secondary somatosensory cortices significantly regressed on activity in the cerebellum when tactile stimuli were self-produced but not when they were externally produced. This supports the proposal that the cerebellum is involved in predicting the sensory consequences of movements. In the present study, this prediction is accurate when tactile stimuli are self-produced relative to when they are externally produced, and is therefore used to attenuate the somatosensory response to the former type of tactile stimulation but not the latter. (C) 1999 Academic Press.