Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging.
Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging.
复制标题
化学感应和热感应系统对寿命的调节：无脊椎动物的发现及其在哺乳动物衰老中的影响。
DOI：
10.3389/fgene.2012.00218
复制
发表时间：
2012
影响因子：
3.7
通讯作者：
Lee SJ
中科院分区：
文献类型：
--
作者：
Jeong DE;Artan M;Seo K;Lee SJ
Many environmental factors that dynamically change in nature influence various aspects of animal physiology. Animals are equipped with sensory neuronal systems that help them properly sense and respond to environmental factors. Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster. Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation. In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging.
