Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma
Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma
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DOI：
10.1118/1.1781332
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发表时间：
2004-09-01
期刊：
影响因子：
3.8
通讯作者：
Yu, CX
中科院分区：
文献类型：
--
作者：
Sarfaraz, M;Kennedy, AS;Yu, CX
我们已经实施了一种三维剂量计算技术，该技术考虑了用Y-90微球治疗的患者的肝脏和肿瘤内的剂量不均匀性。单光子发射计算机断层扫描（SPECT）图像用于推导肝脏内的活性分布。进行蒙特卡罗计算以创建90 Y源的体素剂量核。将放射性分布与体素剂量核卷积，以获得三维（3D）辐射吸收剂量分布。开发了一种自动化技术，用于准确配准计算机断层扫描（CT）和SPECT扫描，以便在CT扫描上显示3D剂量分布。此外，生成剂量-体积直方图以全面分析肿瘤和肝脏剂量。计算的剂量-体积直方图表明，尽管患者接受了110戈伊的标称全肝剂量治疗，但只有16%的肝脏和83%的肿瘤接受了高于110戈伊的剂量。平均肿瘤和肝脏剂量分别为163和58戈伊。(C)2004年美国医学物理学家协会。
We have implemented a three-dimensional dose calculation technique accounting for dose inhomogeneity within the liver and tumor of a patient treated with Y-90 microspheres. Single-photon emission computed tomography (SPECT) images were used to derive the activity distribution within liver. A Monte Carlo calculation was performed to create a voxel dose kernel for the 90Y source. The activity distribution was convolved with the voxel dose kernel to obtain the three-dimensional (3D) radiation absorbed dose distribution. An automated technique was developed to accurately register the computed tomography (CT) and SPECT scans in order to display the 3D dose distribution on the CT scans. In addition, dose-volume histograms were generated to fully analyze the tumor and liver doses. The calculated dose-volume histogram indicated that although the patient was treated to the nominal whole liver dose of 110 Gy, only 16% of the liver and 83% of the tumor received a dose higher than 110 Gy. The mean tumor and liver doses were 163 and 58 Gy, respectively. (C) 2004 American Association of Physicists in Medicine.