Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like "nightmares" in rats.
Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like "nightmares" in rats.
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DOI：
10.1038/srep15976
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发表时间：
2015-11-04
影响因子：
4.6
通讯作者：
Zhang YH
中科院分区：
文献类型：
--
作者：
Yu B;Cui SY;Zhang XQ;Cui XY;Li SJ;Sheng ZF;Cao Q;Huang YL;Xu YP;Lin ZG;Yang G;Song JZ;Ding H;Zhang YH
创伤后噩梦是创伤后应激障碍（PTSD）的核心组成部分，并与这种障碍的发展和维持机制有关，但对其机制知之甚少。我们利用一个交流箱建立了一个生理应激（足电击[FS]）和心理应激（PS）的动物模型，以模拟创伤事件的直接痛苦和目睹。创伤应激后21天，一些实验动物出现了惊吓性觉醒（即，被一个假定的“噩梦”惊醒）具有不同的脑电图频谱特征。我们的神经解剖学结果表明，次级躯体感觉皮层和初级听觉皮层可能在FS“噩梦”（FSN）大鼠的远程创伤记忆提取中起重要作用，而颞叶联合皮层可能在PS“噩梦”（PSN）大鼠中起重要作用。FSN和PSN组具有共同的情绪唤起回路，包括杏仁核的激活和边缘下前额叶皮层和腹侧前扣带皮层的失活。颗粒和非颗粒岛叶皮质的活性降低仅在PSN大鼠中观察到。目前的结果表明，不同类型的压力可能会导致创伤后应激障碍样的“噩梦”在啮齿动物和确定可能的神经回路的记忆检索和情绪唤起。
Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about their mechanism. We utilized a communication box to establish an animal model of physiological stress (foot-shock [FS]) and psychological stress (PS) to mimic the direct suffering and witnessing of traumatic events. Twenty-one days after traumatic stress, some of the experimental animals presented startled awakening (i.e., were startled awake by a supposed “nightmare”) with different electroencephalographic spectra features. Our neuroanatomical results showed that the secondary somatosensory cortex and primary auditory cortex may play an important role in remote traumatic memory retrieval in FS “nightmare” (FSN) rats, whereas the temporal association cortex may play an important role in PS “nightmare” (PSN) rats. The FSN and PSN groups possessed common emotion evocation circuits, including activation of the amygdala and inactivation of the infralimbic prefrontal cortex and ventral anterior cingulate cortex. The decreased activity of the granular and dysgranular insular cortex was only observed in PSN rats. The present results imply that different types of stress may cause PTSD-like “nightmares” in rodents and identified the possible neurocircuitry of memory retrieval and emotion evocation.