Pathogenecity Islands and Their Role in Staphylococcal Biology
Pathogenecity Islands and Their Role in Staphylococcal Biology
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DOI：
10.1128/microbiolspec.gpp3-0062-2019
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发表时间：
2019-05-01
影响因子：
3.7
通讯作者：
Novick, Richard P.
中科院分区：
文献类型：
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作者：
Novick, Richard P.
致病性岛是大量基因组岛的成员，其编码重要的毒力、抗生素抗性和其他辅助功能，并且在细菌基因转移中具有关键作用。金黄色葡萄球菌是这种岛的一个大家族的宿主，称为SaPI，其编码超级抗原和其他毒力决定簇，由辅助细胞动员并以极高的频率转移。它们通过干扰噬菌体捕食和增强水平基因转移而使宿主细胞受益。本章描述了它们的生命周期，它们的噬菌体干扰机制的基础，它们的转移系统和它们转化为用于治疗葡萄球菌感染的抗菌剂。
Pathogenicity islands are members of a vast collection of genomic islands that encode important virulence, antibiotic resistance and other accessory functions and have a critical role in bacterial gene transfer. Staphylococcus aureus is host to a large family of such islands, known as SaPIs, which encode super antigen and other virulence determinants, are mobilized by helper phages and transferred at extremely high frequencies. They benefit their host cells by interfering with phage predation and enhancing horizontal gene transfer. This chapter describes their life cycle, the bases of their phage interference mechanisms, their transfer system and their conversion to antibacterial agents for treatment of staphylococcal infections.