RanBPM, a scaffolding protein in the immune and nervous systems
RanBPM, a scaffolding protein in the immune and nervous systems
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DOI：
10.1007/s11481-007-9079-x
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发表时间：
2007-09-01
影响因子：
6.2
通讯作者：
Talbot, Jeffery N.
中科院分区：
文献类型：
--
作者：
Murrin, L. Charles;Talbot, Jeffery N.
我们回顾了微管组织中心 Ran 结合蛋白（RanBPM；RanBP9）的文献，这是一种 90 kDa 的蛋白质，具有支架蛋白的许多特征，包括蛋白质相互作用基序、细胞骨架结合域和信号中间体的多个规范对接位点。我们专注于检查 RanBPM 和其他蛋白质之间功能相互作用的研究。这些研究表明，RanBPM 为多种信号蛋白的相互作用提供了一个平台，包括细胞表面受体、核受体、核转录因子和胞质激酶。这些研究表明 RanBPM 作为支架蛋白，对于调节免疫系统和神经系统的细胞功能非常重要。
We review the literature for Ran Binding Protein in the Microtubule-Organizing Center (RanBPM; RanBP9), a 90-kDa protein that possesses many characteristics of a scaffolding protein, including protein-interaction motifs, a cytoskeletal-binding domain, and multiple canonical docking sites for signaling intermediates. We focus on studies that have examined functional interactions between RanBPM and other proteins. These studies suggest that RanBPM provides a platform for the interaction of a variety of signaling proteins, including cell surface receptors, nuclear receptors, nuclear transcription factors, and cytosolic kinases. These studies indicate that RanBPM acts as a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system.