Polymorphisms of Antioxidant Genes as a Target for Diabetes Management.
Polymorphisms of Antioxidant Genes as a Target for Diabetes Management.
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DOI：
10.22088/acadpub.bums.6.3.135
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发表时间：
2017
影响因子：
--
通讯作者：
M Amoli M
中科院分区：
文献类型：
--
作者：
Tabatabaei-Malazy O;Khodaeian M;Bitarafan F;Larijani B;M Amoli M
糖尿病（Diabetes mellitus，DM）是世界范围内最重要的健康问题之一，发病率逐年上升。氧化应激是活性氧（ROS）产生和抗氧化防御机制失衡的结果，已被证明是糖尿病的主要病理。高血糖诱导的ROS产生可以通过四种主要的分子机制诱导氧化应激，包括多元醇途径、晚期糖基化终产物形成、蛋白激酶C亚型的活化和己糖胺途径。在2型糖尿病（T2 DM）及其并发症的发生发展中，遗传和环境因素起着重要作用。因此，本综述的目的是集中在抗氧化酶，包括超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶，谷胱甘肽-S-转移酶，一氧化氮合酶和NAD（P）H氧化酶内的单核苷酸多态性的评估及其与2型糖尿病的关联。研究结果除了发现糖尿病治疗的新方法外，还有助于了解疾病发病机制。
Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress, a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including the polyol pathway, advanced glycation end- products formation, activation of protein kinase C isoforms, and the hexosamine pathways. In the development of type 2 DM (T2DM) and its complications, genetic and environmental factors play important roles. Therefore, the aim of this review was to focus on the assessment of single-nucleotide polymorphisms within antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, nitric oxide synthase, and NAD(P)H oxidase and their association with T2DM. The results would be helpful in understanding the mechanisms involved in pathogenesis of disease besides discovering new treatment approaches in management of DM.