Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents
Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents
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DOI：
10.1128/aac.49.11.4781-4783.2005
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发表时间：
2005-11-01
影响因子：
4.9
通讯作者：
Lynch, AS
中科院分区：
文献类型：
--
作者：
Robertson, GT;Doyle, TB;Lynch, AS
构建了肺炎链球菌TIGR4菌株的13个衍生物，其中假定的药物外排泵被遗传灭活。结果表明，编码ABC型转运蛋白SP2073和SP2075的两个连锁基因共同作用，赋予对一系列结构无关化合物（包括某些氟喹诺酮类）的内在耐药性。
Thirteen derivatives of the Streptococcus pneumoniae TIGR4 strain in which putative drug efflux pumps were genetically inactivated were constructed and characterized. The results indicate that two linked genes encoding the ABC-type transporters SP2073 and SP2075 function together to confer intrinsic resistance to a series of structurally unrelated compounds, including certain fluoroquinolones.