Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown
Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown
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DOI：
10.4269/ajtmh.2002.66.590
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发表时间：
2002-05-01
影响因子：
3.3
通讯作者：
Guerrant, RL
中科院分区：
文献类型：
--
作者：
Niehaus, MD;Moore, SR;Guerrant, RL
腹泻是公认的发展中国家儿童死亡率和发病率的主要原因;然而，幼儿期严重腹泻负担可能导致的长期认知缺陷仍然定义不清。为了评估早期儿童腹泻（在生命的前2年）对儿童后期认知功能的潜在长期影响，我们研究了巴西城市棚户区中一组儿童的认知功能，这些儿童的早期儿童腹泻发病率很高。46名儿童（年龄范围，6-10岁）在其生命的前2年内进行了完整的腹泻监测，进行了一系列的5项认知测试。非语言智力测试-III（TONI）评分与儿童早期腹泻呈负相关（P= 0.01），即使控制了母亲的教育程度、母乳喂养时间和儿童早期蠕虫病（蛔虫或鞭虫）。此外，17名有持续性腹泻病史的儿童的韦氏儿童智力量表（WISC-III）编码任务和WISC-III数字广度（反向和总）评分也显著低于对照组（PD; P
Diarrhea is well recognized as a leading cause of childhood mortality and morbidity in developing countries; however, possible long-term cognitive deficits from heavy diarrhea burdens in early childhood remain poorly defined. To assess the potential long-term impact of early childhood diarrhea (in the first 2 years of life) on cognitive function in later childhood, we studied the cognitive function of a cohort of children in an urban Brazilian shantytown with a high incidence of early childhood diarrhea. Forty-six children (age range, 6-10 years) with complete diarrhea surveillance during their first 2 years of life were given a battery of five cognitive tests. Test of Non-Verbal Intelligence-III (TONI) scores were inversely correlated with early childhood diarrhea (P=.01), even when controlling for maternal education, duration of breast-feeding, and early childhood helminthiasis (Ascaris or Trichuris). Furthermore, Wechsler Intelligence Scale for Children (WISC-III) Coding Tasks and WISC-III Digit Span (reverse and total) scores were also significantly lower in the 17 children with a history of early childhood persistent diarrhea (PD; P