Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats.
Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats.
复制标题
中枢输注 GLP-1（而非瘦素）会在大鼠中产生条件性味觉厌恶。
DOI：
10.1152/ajpregu.1997.272.2.r726
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Seeley,RJ
中科院分区：
文献类型：
--
作者：
Thiele,TE;VanDijk,G;Campfield,LA;Smith,FJ;Burn,P;Woods,SC;Bernstein,IL;Seeley,RJ
瘦素（ob蛋白）和胰高血糖素样肽-1-（7-36）酰胺（GLP-1）是最近提出的参与调节食物摄入的肽。尽管外源性瘦素和GLP-1调节消费行为的能力与这些肽是内源性调节剂的建议一致，但这些肽的中枢给药可能具有令人厌恶的副作用，这可以解释厌食症。在本实验中，暴露于糖精味后立即进行瘦素或GLP-1的中枢给药，以确定这些药物是否可以在大鼠中产生条件性味觉厌恶（CTA）。在相当于产生短期食物摄入量相当减少的剂量下，GLP-1而不是瘦素产生了稳健的CTA。虽然瘦素没有引起厌恶，这种肽是唯一的药物，导致相对长期的减少食物消耗（16小时）和体重（24小时）。因此，结果表明，中枢GLP-1产生令人厌恶的副作用，并且认为这些非特异性作用可以解释GLP-1的厌食作用。
Leptin (ob protein) and glucagon-like peptide-1-(7-36) amide (GLP-1) are peptides recently proposed to be involved in the regulation of food intake. Although the ability of exogenous leptin and GLP-1 to modulate consummatory behavior is consistent with the suggestion that these peptides are endogenous regulatory agents, central administration of these peptides may have aversive side effects, which could explain the anorexia. In the present experiment, exposure to a saccharine taste was immediately followed by central administration of leptin or GLP-1 to determine if these drugs could produce a conditioned taste aversion (CTA) in rats. At doses equated for producing comparable reductions in short-term food intake, GLP-1, but not leptin, generated a robust CTA. Although leptin caused no aversion, this peptide was the only drug to cause relatively long-term reductions in food consumption (16 h) and body weight (24 h). Hence, the results indicate that central GLP-1 produces aversive side effects, and it is argued that these nonspecific effects may explain the anorectic actions of GLP-1.
胆囊收缩素拮抗剂丙谷胺可增加大鼠的食物摄入量
影响因子：
--
作者：
G. Shillabeer;J. Davison
通讯作者：
J. Davison