Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
复制标题
来自南海深海的环状六肽，源自Streptomyces scopuliridis scsio zj46，对致病性革兰氏阳性菌具有活性
DOI：
10.1021/np500399v
复制
发表时间：
2014-08-01
影响因子：
5.1
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
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作者：
Song, Yongxiang;Li, Qinglian;Ju, Jianhua
从海洋微生物Streptomyces scopuliridis SCSIO ZJ 46中分离得到三个新的环己肽，desotamides B-D（2-4）和已知的desotamide（1）。根据高分辨率光谱数据、Marveland方法和手性HPLC数据，阐明了2-4的序列和绝对构型。Desotamide C（3）含有独特的N-甲酰基-犬尿氨酸残基，而4在相同位点缺乏N-甲酰基-犬尿氨酸残基。化合物1和2对肺炎链球菌、金黄色葡萄球菌和耐甲氧西林表皮葡萄球菌（MRSE）菌株显示出显著的抗菌活性，并且构效关系研究揭示了尖端组分在这种新支架内的抗菌活性的不可或缺性。
Three new cyclohexapeptides, desotamides B-D (2-4), and the known desotamide (1) were isolated from marine microbe Streptomyces scopuliridis SCSIO ZJ46. The sequences and absolute configurations of 2-4 were elucidated on the basis of high-resolution spectroscopic data, Marfey's method, and chiral-phase HPLC data. Desotamide C (3) contains a unique N-formyl-kynurenine residue, whereas 4 lacks formylation at the same site. Compounds 1 and 2 displayed notable antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE), and structure activity relationship studies revealed the indispensability of the Tip component for antibacterial activity within this new scaffold.